Zhuo Fang

TL;DR: It is shown that a single miRNA can repress the production of hundreds of proteins, but that this repression is typically relatively mild, and the data suggest that a mi RNA can, by direct or indirect effects, tune protein synthesis from thousands of genes.

TL;DR: A central role for miR-182 is demonstrated in the physiological regulation of IL-2-driven helper T cell–mediated immune responses and new therapeutic possibilities are opened.

TL;DR: Using transcriptomics and proteomics data of ten miRNA mis-expression experiments as well as transcriptome-wide experimentally identified miRNA target sites, it is found that mRNA and protein expression of genes containing target Sites both in coding regions and 3′UTRs were in general mildly but significantly more regulated than those containing target sites in 3′utRs only.

TL;DR: It is shown that human bone marrow professional memory T cells are not activated but are resting in terms of proliferation, transcription, and mobility, and they are in the G0 phase of the cell cycle, and their transcriptome is that of resting T cells.

TL;DR: A new algorithm capturing both expression pattern similarities and biological function similarities is developed, and it is shown that this method has advantages in both the quality of clusters and the precision of biological annotations.