Maureen Higgins

TL;DR: It is shown that itaconate is required for the activation of the anti-inflammatory transcription factor Nrf2 by lipopolysaccharide in mouse and human macrophages and that type I interferons boost the expression of Irg1 (also known as Acod1) and itaconates production.

TL;DR: It is shown that tenovins act through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family, and underscores the utility of these compounds as biological tools for the study of sIRTuin function as well as their potential therapeutic interest.

TL;DR: DNA pull-down assays using a 7,8-dihydro-8-oxoguanine duplex oligonucleotide as a substrate found that RPS3 acted as a scaffold for the additional binding of MDM2 and p53, suggesting that R PS3 interacts with important proteins involved in maintaining genomic integrity.

TL;DR: Modifications to the core structure of cambinol are described by incorporation of substituents at the N1-position, which lead to increased potency and modified selectivity, which has been rationalized using molecular modeling techniques.

TL;DR: The use of a unique chemical scaffold revealed that NRF2 activation responses were muted in HD patient-derived neural stem cells, suggesting increased susceptibility of this critical renewable cell population to oxidative stress in HD brain, and a muted NRf2 activation response in human HD Neural stem cells was discovered, which was restored by genetic correction of the disease-causing mutation.