E
Elizabeth A. Wohlfert
Researcher at University at Buffalo
Publications - 43
Citations - 4825
Elizabeth A. Wohlfert is an academic researcher from University at Buffalo. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 20, co-authored 40 publications receiving 4170 citations. Previous affiliations of Elizabeth A. Wohlfert include University of Connecticut Health Center & University of Connecticut.
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Journal ArticleDOI
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells
Angela M. Thornton,Patricia E. Korty,Dat Q. Tran,Elizabeth A. Wohlfert,Patrick E. Murray,Yasmine Belkaid,Ethan M. Shevach +6 more
TL;DR: Results demonstrate that Helios is potentially a specific marker of thymic-derived T Reg cells and raises the possibility that a significant percentage of Foxp3+ Treg cells are generated extrathymically.
Journal ArticleDOI
The alarmin IL-33 promotes regulatory T-cell function in the intestine
Chris Schiering,Thomas Krausgruber,Agnieszka Chomka,Anja Fröhlich,Krista Adelmann,Elizabeth A. Wohlfert,Johanna Pott,Thibault Griseri,Julia Bollrath,Ahmed N. Hegazy,Oliver J. Harrison,Benjamin M. J. Owens,Max Löhning,Yasmine Belkaid,Padraic G. Fallon,Fiona Powrie +15 more
TL;DR: It is shown in mice that the IL-33 receptor ST2 is preferentially expressed on colonic Treg cells, where it promotes Treg function and adaptation to the inflammatory environment, and suggests that the balance between IL- 33 and IL-23 may be a key controller of intestinal immune responses.
Journal ArticleDOI
Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses
Jason A. Hall,Jason A. Hall,Nicolas Bouladoux,Cheng-Ming Sun,Elizabeth A. Wohlfert,Rebecca Blank,Qing Zhu,Michael E. Grigg,Jay A. Berzofsky,Yasmine Belkaid +9 more
TL;DR: It is found that gut flora DNA (gfDNA) plays a major role in intestinal homeostasis through Toll-like receptor 9 (TLR9) engagement and is used as a natural adjuvant for priming intestinal responses via modulation of Treg/Teff cell equilibrium.
Journal ArticleDOI
GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
Elizabeth A. Wohlfert,John R. Grainger,Nicolas Bouladoux,Joanne E. Konkel,Guillaume Oldenhove,Carolina Hager Ribeiro,Jason A. Hall,Ryoji Yagi,Shruti Naik,Ravikiran Bhairavabhotla,William E. Paul,Rémy Bosselut,Gang Wei,Keji Zhao,Mohamed Oukka,Jinfang Zhu,Yasmine Belkaid +16 more
TL;DR: The data indicate that GATA3 limits Treg polarization toward an effector T cell phenotype and acquisition of effector cytokines in inflamed tissues, and highlights what may be a fundamental role in controlling Treg physiology during inflammation.
Journal ArticleDOI
Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha
Jason A. Hall,Jennifer Jl Cannons,John R. Grainger,Liliane M. dos Santos,Timothy W. Hand,Shruti Naik,Shruti Naik,Elizabeth A. Wohlfert,David B. Chou,Guillaume Oldenhove,Melody M Robinson,Michael Me Grigg,Robin R Kastenmayer,Pamela Pl Schwartzberg,Yasmine Belkaid +14 more
TL;DR: Findings reveal a fundamental role for the RA-RARα axis in the development of both regulatory and inflammatory arms of adaptive immunity and establish nutritional status as a broad regulator of adaptive T cell responses.