T
Thomas Krausgruber
Researcher at Austrian Academy of Sciences
Publications - 58
Citations - 6020
Thomas Krausgruber is an academic researcher from Austrian Academy of Sciences. The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 22, co-authored 49 publications receiving 4282 citations. Previous affiliations of Thomas Krausgruber include University of Oxford & John Radcliffe Hospital.
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Journal ArticleDOI
IRF5 Promotes Inflammatory Macrophage Polarization and TH1-TH17 Responses
Thomas Krausgruber,Katrina Blazek,Timothy Smallie,Saba Alzabin,Helen Lockstone,Natasha Sahgal,Tracy Hussell,Marc Feldmann,Irina A. Udalova +8 more
TL;DR: Global gene expression analysis demonstrated that exogenous IRF5 upregulated or downregulated expression of established phenotypic markers of M1 or M2 macrophages, respectively, suggesting a critical role for IRf5 in M1 macrophage polarization and defining a previously unknown function forIRF5 as a transcriptional repressor.
Journal Article
Irf5 promotes inflammatory macrophage polarization and th1/th17 response
Thomas Krausgruber,Katrina Blazek,Timothy Smallie,Helen Lockstone,Natasha Sahgal,Saba Alzabin,Tracy Hussell,Marc Feldmann,Irina A. Udalova +8 more
TL;DR: The authors showed that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and contributed to the plasticity of macrophage polarization, leading to a potent T helper type 1 (TH1)-TH17 response.
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The alarmin IL-33 promotes regulatory T-cell function in the intestine
Chris Schiering,Thomas Krausgruber,Agnieszka Chomka,Anja Fröhlich,Krista Adelmann,Elizabeth A. Wohlfert,Johanna Pott,Thibault Griseri,Julia Bollrath,Ahmed N. Hegazy,Oliver J. Harrison,Benjamin M. J. Owens,Max Löhning,Yasmine Belkaid,Padraic G. Fallon,Fiona Powrie +15 more
TL;DR: It is shown in mice that the IL-33 receptor ST2 is preferentially expressed on colonic Treg cells, where it promotes Treg function and adaptation to the inflammatory environment, and suggests that the balance between IL- 33 and IL-23 may be a key controller of intestinal immune responses.
Journal ArticleDOI
Pooled CRISPR screening with single-cell transcriptome readout
Paul Datlinger,André F. Rendeiro,Christian Schmidl,Thomas Krausgruber,Peter Traxler,Johanna Klughammer,Linda C. Schuster,Amelie Kuchler,Donát Alpár,Christoph Bock,Christoph Bock,Christoph Bock +11 more
TL;DR: This method forCRISPR droplet sequencing (CROP-seq) enables pooled CRISPR screens with single-cell transcriptome resolution, which will facilitate high-throughput functional dissection of complex regulatory mechanisms and heterogeneous cell populations.
Journal ArticleDOI
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.
Ricardo J. Miragaia,Tomás Gomes,Agnieszka Chomka,Laura Jardine,Angela Riedel,Ahmed N. Hegazy,Ahmed N. Hegazy,Natasha Whibley,Andrea Tucci,Xi Chen,Ida Lindeman,Guy Emerton,Thomas Krausgruber,Thomas Krausgruber,Jacqueline D. Shields,Muzlifah Haniffa,Fiona Powrie,Fiona Powrie,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann +20 more
TL;DR: It is shown that Treg cells segregate into subpopulations along a continuum of tissue adaptation and present conserved expression programs between homeostasis and disease and mouse and human.