M
Maya Gordin
Researcher at Weizmann Institute of Science
Publications - 6
Citations - 226
Maya Gordin is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: B cell & Macrophage migration inhibitory factor. The author has an hindex of 4, co-authored 6 publications receiving 203 citations.
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p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways.
Yosef Buganim,Hilla Solomon,Yoach Rais,Daria Kistner,Ido Nachmany,Mariana Brait,Shalom Madar,Ido Goldstein,Eyal Kalo,Nitzan Adam,Maya Gordin,Noa Rivlin,Ira Kogan,Ran Brosh,Galit Sefadia-Elad,Naomi Goldfinger,David Sidransky,Yoel Kloog,Varda Rotter +18 more
TL;DR: It is shown that CGS expression strongly correlates with malignancy and further elucidates the molecular loop between p53 and Ras in the transformation process.
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The Cytokine Midkine and Its Receptor RPTPζ Regulate B Cell Survival in a Pathway Induced by CD74
Sivan Cohen,Or-yam Shoshana,Einat Zelman-Toister,Nitsan Maharshak,Inbal Binsky-Ehrenreich,Maya Gordin,Inbal Hazan-Halevy,Yair Herishanu,Lev Shvidel,Michal Haran,Lin Leng,Richard Bucala,Sheila Harroch,Idit Shachar +13 more
TL;DR: A novel biological mechanism essential for survival and homeostasis of normal peripheral mature B cells and chronic lymphocytic leukemia cells, regulated by the heparin-binding cytokine, midkine (MK), and its proteoglycan receptor, the receptor-type tyrosine phosphatase ζ (RPTPζ).
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c-Met and Its Ligand Hepatocyte Growth Factor/Scatter Factor Regulate Mature B Cell Survival in a Pathway Induced by CD74
Maya Gordin,Melania Tesio,Sivan Cohen,Yael Gore,Frida Lantner,Lin Leng,Richard Bucala,Idit Shachar +7 more
TL;DR: It is demonstrated that c-Met activation by HGF leads to a survival cascade, whereas its blockade results in induction of mature B cell death, resulting in the control of the humoral immune response.
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A role for the B‐cell CD74/macrophage migration inhibitory factor pathway in the immunomodulation of systemic lupus erythematosus by a therapeutic tolerogenic peptide
Smadar Lapter,Hava Ben-David,Amir Sharabi,Heidy Zinger,Alona Telerman,Maya Gordin,Lin Leng,Richard Bucala,Idit Shachar,Edna Mozes +9 more
TL;DR: It is reported here that B lymphocytes from SLE‐afflicted mice express relatively elevated levels of CD74, compared with B cells from healthy mice, and the results suggest that the CD74/MIF pathway plays an important role in lupus pathology.