L
Lev Shvidel
Researcher at Kaplan Medical Center
Publications - 111
Citations - 2284
Lev Shvidel is an academic researcher from Kaplan Medical Center. The author has contributed to research in topics: Chronic lymphocytic leukemia & Leukemia. The author has an hindex of 24, co-authored 108 publications receiving 1868 citations. Previous affiliations of Lev Shvidel include Hebrew University of Jerusalem & Weizmann Institute of Science.
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Journal ArticleDOI
Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival.
Diana Starlets,Yael Gore,Yael Gore,Inbal Binsky,Inbal Binsky,Michal Haran,Michal Haran,Nurit Harpaz,Nurit Harpaz,Lev Shvidel,Lev Shvidel,Shirly Becker-Herman,Shirly Becker-Herman,Alain Berrebi,Alain Berrebi,Idit Shachar,Idit Shachar +16 more
TL;DR: It is shown that CD74 stimulation with anti-CD74 antibody leads to an induction of a signaling cascade resulting in NF-kappaB activation, entry of the stimulated cells into the S phase, elevation of DNA synthesis, cell division, and augmented expression of BCL-X(L).
Journal ArticleDOI
IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival
Inbal Binsky,Michal Haran,Diana Starlets,Yael Gore,Frida Lantner,Nurit Harpaz,Lin Leng,David M. Goldenberg,Lev Shvidel,Alain Berrebi,Richard Bucala,Idit Shachar +11 more
TL;DR: Analysis of molecular mechanism regulated by CD74 in B-CLL cells shows that activation of cell-surface CD74, expressed at high levels from an early stage of the disease by its natural ligand, macrophage migration-inhibition factor (MIF), initiates a signaling cascade that contributes to tumor progression.
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Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma
Guy Ledergor,Guy Ledergor,Assaf Weiner,Mor Zada,Shuang-Yin Wang,Yael C Cohen,Yael C Cohen,Moshe E. Gatt,Moshe E. Gatt,Nimrod Snir,Nimrod Snir,Hila Magen,Hila Magen,Maya Koren-Michowitz,Katrin Herzog-Tzarfati,Hadas Keren-Shaul,Chamutal Bornstein,Ron Rotkopf,Ido Yofe,Eyal David,Venkata Yellapantula,Sigalit Kay,Moshe Salai,Moshe Salai,Dina Ben Yehuda,Dina Ben Yehuda,Arnon Nagler,Arnon Nagler,Lev Shvidel,Lev Shvidel,Avi Orr-Urtreger,Avi Orr-Urtreger,Keren Bahar Halpern,Shalev Itzkovitz,Ola Landgren,Jesús F. San-Miguel,Bruno Paiva,Jonathan J Keats,Elli Papaemmanuil,Irit Avivi,Irit Avivi,Gabriel I. Barbash,Amos Tanay,Ido Amit +43 more
TL;DR: This work establishes single cell RNA sequencing for dissecting blood malignancies and devising detailed molecular characterization of tumor cells in symptomatic and asymptomatic patients, and identifies extensive subclonal structures for 10 of 29 individuals with multiple myeloma.
Journal ArticleDOI
CD74 is a novel transcription regulator
Naama Gil-Yarom,Lihi Radomir,Lital Sever,Matthias P. Kramer,Hadas Lewinsky,Chamutal Bornstein,Ronnie Blecher-Gonen,Zohar Barnett-Itzhaki,Vita Mirkin,Gilgi Friedlander,Lev Shvidel,Yair Herishanu,Elias Lolis,Shirly Becker-Herman,Ido Amit,Idit Shachar +15 more
TL;DR: It is demonstrated that CD74’s cytoplasmic domain binds chromatin and regulates transcription and expression of genes involved in immune regulation, cell survival, and hematopoietic cancers and that identifying targets of CD74 will help in understanding of essential pathways regulating B-cell survival in health and disease.
Journal ArticleDOI
Primary Effusion Lymphoma (PEL) in HIV-Negative Patients - a Distinct Clinical Entity
TL;DR: Analysis of these rare cases suggests HIV-negative EBV-negative PEL to be a distinct clinical entity with epidemiological features resembling classical KS and supports anEBV-independent role for HHV-8 in the pathogenesis of PEL.