Sivan Cohen

TL;DR: Inflammatory signals and Foxp3 balance mTORC1 signaling and glucose metabolism to control the proliferation and suppressive function of Treg cells.

TL;DR: It is reported here that mTOR kinase complexes 1 and 2 (mTORC1 and mTORC2) are essential for Tfh cell differentiation and GC reaction under steady state and after antigen immunization and viral infection.

TL;DR: It is shown that aerobic glycolysis is surprisingly less active in T-ALL cells than proliferating normal T cells and that T-all cells are metabolically distinct, and that AMPK simultaneously inhibits anabolic growth signaling and is essential to promote mitochondrial pathways that mitigate metabolic stress and apoptosis inT-ALL.

TL;DR: In this article, the authors identify the genetic alteration in a patient with combined immunodeficiency and characterize human caspase recruitment domain family, member 11 (CARD11), deficiency, and reveal the crucial and nonredundant role of canonical NF-κB activation and specifically CARD11 in the antigen-specific immune response in human subjects.

TL;DR: In patients with CARD11 deficiency, the combination of impaired activation and especially upregulation of inducible T- cell costimulator on T cells, together with severely disturbed peripheral B-cell differentiation, apparently leads to a defective T-cell/B-cell cooperation and probably germinal center formation and clinically results in severe immunodeficiency.