M
Maziyar Saberi
Researcher at University of California, San Diego
Publications - 13
Citations - 2326
Maziyar Saberi is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 11, co-authored 12 publications receiving 2178 citations. Previous affiliations of Maziyar Saberi include University of Southern California.
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Journal ArticleDOI
Insulin sensitivity: modulation by nutrients and inflammation.
TL;DR: The hypothesis that the macrophage is an important cell type in the propagation of inflammation and induction of insulin resistance in obesity is focused on, which provides the integrative perspective regarding how nutrients and obesity interact to regulate insulin sensitivity.
Journal ArticleDOI
Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice
Maziyar Saberi,Niels-Bjarne Woods,Carl de Luca,Simon Schenk,Juu Chin Lu,Gautam Bandyopadhyay,Inder M. Verma,Jerrold M. Olefsky +7 more
TL;DR: The results indicate that Tlr4 signaling in hematopoietic-derived cells is important for the development of hepatic and adipose tissue insulin resistance in obese mice.
Journal ArticleDOI
PPARγ activation in adipocytes is sufficient for systemic insulin sensitization
Shigeki Sugii,Peter Olson,Peter Olson,Dorothy D. Sears,Maziyar Saberi,Annette R. Atkins,Grant D. Barish,Suk Hyun Hong,Glenda L. Castro,Yun Qiang Yin,Michael C. Nelson,Michael C. Nelson,Gene Hsiao,David R. Greaves,Michael Downes,Ruth T. Yu,Jerrold M. Olefsky,Ronald M. Evans,Ronald M. Evans,Ronald M. Evans +19 more
TL;DR: It is found that selective activation of PPARγ in adipocytes, but not in macrophages, is sufficient for whole-body insulin sensitization equivalent to systemic TZD treatment, and a specific application for fat selective PParγ modulators in diabetic therapy is suggested.
Journal ArticleDOI
Adipocyte CREB promotes insulin resistance in obesity.
Ling Qi,Maziyar Saberi,Erik Zmuda,Yiguo Wang,Judith Y. Altarejos,Xinmin Zhang,Renaud Dentin,Susie Hedrick,Gautam Bandyopadhyay,Tsonwin Hai,Jerry Olefsky,Marc Montminy +11 more
TL;DR: Results indicate that adipocyte CREB provides an early signal in the progression to type 2 diabetes.
Journal ArticleDOI
A Novel Pathway of Insulin Sensitivity in Chromogranin A Null Mice A CRUCIAL ROLE FOR PANCREASTATIN IN GLUCOSE HOMEOSTASIS
Jiaur R. Gayen,Maziyar Saberi,Simon Schenk,Nilima Biswas,Sucheta M. Vaingankar,Wai W. Cheung,Sonia M. Najjar,Daniel T. O'Connor,Daniel T. O'Connor,Gautam Bandyopadhyay,Sushil K. Mahata +10 more
TL;DR: The rise in blood PST level with age and in diabetes suggests that PST is a negative regulator of insulin sensitivity and glucose homeostasis.