S
Sucheta M. Vaingankar
Researcher at University of California, San Diego
Publications - 42
Citations - 2525
Sucheta M. Vaingankar is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Chromogranin A & Catecholamine. The author has an hindex of 20, co-authored 42 publications receiving 2353 citations. Previous affiliations of Sucheta M. Vaingankar include University of California, Riverside & Veterans Health Administration.
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Journal ArticleDOI
Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification
Frank Rutsch,Nico Ruf,Sucheta M. Vaingankar,Mohammad R. Toliat,Anita Suk,Anita Suk,Wolfgang Höhne,Galen Schauer,Mandy Lehmann,Mandy Lehmann,Tony Roscioli,Dirk Schnabel,Jörg T. Epplen,A. S. Knisely,Andrea Superti-Furga,James McGill,Marco Filippone,Alan R. Sinaiko,Hillary Vallance,Bernd Hinrichs,Wendy E. Smith,Merry Ferre,Robert Terkeltaub,Peter Nürnberg,Peter Nürnberg +24 more
TL;DR: It is found that IIAC was associated with mutations that inactivated ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), a cell surface enzyme that generates inorganic pyroph phosphate (PPi), a solute that regulates cell differentiation and serves as an essential physiologic inhibitor of calcification.
Journal ArticleDOI
Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog
Nitish R. Mahapatra,Daniel T. O'Connor,Sucheta M. Vaingankar,Amiya P. Sinha Hikim,Manjula Mahata,Saugata Ray,Eugenie Staite,Hongjiang Wu,Yusu Gu,Nancy D. Dalton,Brian P. Kennedy,Michael G. Ziegler,John Ross,Sushil K. Mahata +13 more
TL;DR: Loss of the physiological "brake" catestatin in Chga mice coupled with dysregulation of transmitter storage and release may act in concert to alter autonomic control of the circulation in vivo, eventuating in hypertension.
Journal ArticleDOI
PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification.
Frank Rutsch,Sucheta M. Vaingankar,Kristen Johnson,Ira D. Goldfine,Betty A. Maddux,Petra Schauerte,Hermann Kalhoff,Kimihiko Sano,William A. Boisvert,Andrea Superti-Furga,Robert Terkeltaub +10 more
TL;DR: In this paper, a 25-month-old boy with idiopathic infantile arterial calcification (IIAC) and peri-articular calcification was assessed.
Journal ArticleDOI
Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1.
Kristen Johnson,Lovisa Hessle,Lovisa Hessle,Sucheta M. Vaingankar,C Wennberg,C Wennberg,Sonia Di Mauro,Sonoko Narisawa,James W. Goding,Kimihiko Sano,José Luis Millán,José Luis Millán,Robert Terkeltaub +12 more
TL;DR: Tissue-nonspecific alkaline phosphatase (TNAP) attenuates PC-1/NTPPPH-induced PP(i) generation that would otherwise inhibit MV-mediated mineralization, and TNAP also paradoxically regulatesPC-1 expression and NTP PPH activity in osteoblasts.
Journal ArticleDOI
Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes
Kristen Johnson,Sucheta M. Vaingankar,Ying Chen,Allison Moffa,Mary B. Goldring,Kimihiko Sano,Piao Jin-Hua,Adnan Sali,James W. Goding,Robert Terkeltaub,Robert Terkeltaub +10 more
TL;DR: Differential expression of PC-1 and B10 could modulate cartilage mineralization in degenerative joint diseases and appear to act principally in different intracellular compartments.