S
Shigeki Sugii
Researcher at National University of Singapore
Publications - 60
Citations - 2949
Shigeki Sugii is an academic researcher from National University of Singapore. The author has contributed to research in topics: Stem cell & Adipose tissue. The author has an hindex of 24, co-authored 57 publications receiving 2500 citations. Previous affiliations of Shigeki Sugii include Boston Children's Hospital & Dartmouth College.
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Journal ArticleDOI
CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance
Suryaprakash Raichur,Siew Tein Wang,Puck Wee Chan,Ying Li,Jianhong Ching,Bhagirath Chaurasia,Shaillay Kumar Dogra,Miina K. Öhman,Kosuke Takeda,Shigeki Sugii,Yael Pewzner-Jung,Anthony H. Futerman,Scott A. Summers +12 more
TL;DR: The studies reveal that altering sphingolipid acylation patterns impacts hepatic steatosis and insulin sensitivity and identify CerS6 as a possible therapeutic target for treating metabolic diseases associated with obesity.
Journal ArticleDOI
PPARγ activation in adipocytes is sufficient for systemic insulin sensitization
Shigeki Sugii,Peter Olson,Peter Olson,Dorothy D. Sears,Maziyar Saberi,Annette R. Atkins,Grant D. Barish,Suk Hyun Hong,Glenda L. Castro,Yun Qiang Yin,Michael C. Nelson,Michael C. Nelson,Gene Hsiao,David R. Greaves,Michael Downes,Ruth T. Yu,Jerrold M. Olefsky,Ronald M. Evans,Ronald M. Evans,Ronald M. Evans +19 more
TL;DR: It is found that selective activation of PPARγ in adipocytes, but not in macrophages, is sufficient for whole-body insulin sensitization equivalent to systemic TZD treatment, and a specific application for fat selective PParγ modulators in diabetic therapy is suggested.
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Role of Niemann-Pick Type C1 Protein in Intracellular Trafficking of Low Density Lipoprotein-derived Cholesterol *
TL;DR: It is found that the initial movement of low density lipoprotein (LDL)-derived cholesterol to the plasma membrane (PM) did not require NPC1, but after reaching the PM and subsequent internalization, cholesterol trafficking back to the PM did involve NPC1.
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Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells
Shigeki Sugii,Yasuyuki S. Kida,Teruhisa Kawamura,Jotaro Suzuki,Rita Vassena,Yun-Qiang Yin,Margaret Lutz,W. Travis Berggren,Juan Carlos Izpisúa Belmonte,Ronald M. Evans +9 more
TL;DR: It is reported that adult human and mouse adipose-derived stem cells can be reprogrammed to induced pluripotent stem (iPS) cells with substantially higher efficiencies than those reported for human andmouse fibroblasts.
Journal ArticleDOI
Niemann-Pick Type C Disease and Intracellular Cholesterol Trafficking
Ta-Yuan Chang,Patrick C. Reid,Shigeki Sugii,Nobutaka Ohgami,Jonathan C. Cruz,Catherine C.Y. Chang +5 more
TL;DR: This work presents a novel and scalable approach to gene expression engineering that allows for real-time measurement of the activity of T. Y. Chang’s Tournaisian factor, which is important for understanding the immune response to infectious disease.