M
Meenakshi A. Chellaiah
Researcher at University of Maryland, Baltimore
Publications - 42
Citations - 3342
Meenakshi A. Chellaiah is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Osteoclast & Osteopontin. The author has an hindex of 32, co-authored 41 publications receiving 3007 citations. Previous affiliations of Meenakshi A. Chellaiah include University of Maryland, College Park & Washington University in St. Louis.
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Journal ArticleDOI
CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells.
TL;DR: Recent observations have shown that CD44 intracellular domain (CD44-ICD) is related to the metastatic potential of breast cancer cells, however, the underlying mechanisms need further elucidation.
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Gelsolin Deficiency Blocks Podosome Assembly and Produces Increased Bone Mass and Strength
Meenakshi A. Chellaiah,Neil Kizer,Matthew J. Silva,Ulises Alvarez,David J. Kwiatkowski,Keith A. Hruska +5 more
TL;DR: It is demonstrated that gelsolin deficiency blocks podosome assembly and αvβ3-stimulated signaling related to motility in gelolin-null mice, demonstrating the critical role of gelsolins in podosomes assembly, rapid cell movements, and signal transduction through the αv β3 integrin.
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Rho-A is critical for osteoclast podosome organization, motility, and bone resorption.
Meenakshi A. Chellaiah,Norihito Soga,Suzanne Swanson,Sandy McAllister,Ulises Alvarez,Dong-Mei Wang,Steven F. Dowdy,Keith A. Hruska +7 more
TL;DR: It is demonstrated that integrin-dependent activation of phosphoinositide synthesis, actin stress fiber formation, podosome reorganization for osteoclast motility, and bone resorption require Rho stimulation.
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Osteopontin Deficiency Produces Osteoclast Dysfunction Due to Reduced CD44 Surface Expression
Meenakshi A. Chellaiah,Neil Kizer,Rajat S. Biswas,Ulises Alvarez,Jena Strauss-Schoenberger,Leonard Rifas,Susan R. Rittling,David T. Denhardt,Keith A. Hruska +8 more
TL;DR: The role of OPN in osteoclast function and the requirement for OPN as an osteOClast autocrine factor during bone remodeling are demonstrated.
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Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells
TL;DR: It is suggested that CD44 surface expression is an important event in the activation of MMP-9 and migration of prostate cancer cells and the various steps involved in the above mentioned signaling pathway and/or the molecules regulating the activated molecule are potential therapeutic target.