M
Meenakshi A. Chellaiah
Researcher at University of Maryland, Baltimore
Publications - 42
Citations - 3342
Meenakshi A. Chellaiah is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Osteoclast & Osteopontin. The author has an hindex of 32, co-authored 41 publications receiving 3007 citations. Previous affiliations of Meenakshi A. Chellaiah include University of Maryland, College Park & Washington University in St. Louis.
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Rho-dependent Rho Kinase Activation Increases CD44 Surface Expression and Bone Resorption in Osteoclasts
TL;DR: The results strongly suggest a role for ROK-α in αvβ3-mediated Rho signaling, which is required for the phosphorylation events and CD44 surface expression and find that cooperativity exists between αv β3 andCD44 for osteoclast motility and bone resorption.
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Rac Regulates Vascular Endothelial Growth Factor Stimulated Motility
TL;DR: Two pathways of regulating endothelial cell motility are demonstrated, one in which Rac is activated by matrix/integrin stimulation and is a crucial modulator of endothelialcell haptotaxis and the other, in the presence of osteopontin, is Rac independent.
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Regulation of actin ring formation by rho GTPases in osteoclasts.
TL;DR: Results suggest that Rho-mediated PIP2 interaction with WASP may contribute to the activation and membrane targeting of WASP.
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Invadopodia and Matrix Degradation, a New Property of Prostate Cancer Cells during Migration and Invasion
TL;DR: It is concluded that OPN/integrin αvβ3 signaling participates in the process of migration and invasion of PC3 cells through regulating processes essential for the formation and function of invadopodia.
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Regulation of ?V?3 and ?V?5 integrins by dexamethasone in normal human osteoblastic cells
Su-Li Cheng,Chung-Fang Lai,Aurora Fausto,Meenakshi A. Chellaiah,Xu Feng,Kevin P. McHugh,Steven L. Teitelbaum,Roberto Civitelli,Keith A. Hruska,F. Patrick Ross,Louis V. Avioli +10 more
TL;DR: Adhesion of human osteoblastic cells to osteopontin and vitronectin was found to be dependent on αvβ3 and αv β5, respectively; this ligand specificity was not altered by dexamethasone, and Dex exhibited time‐dependent regulation on the expression of β3 andαvβ5 integrins in normal human osteoblast cells.