Megan Neville

TL;DR: Viable mis-sense mutations in the CRM1 gene substantially reduced or eliminated the biological activity of Rev in S. cerevisiae, providing strong evidence that Crm1p also contributes to transport of Rev NES-containing proteins and ribonucleoproteins in this organism.

TL;DR: The results suggest that Rev directly promotes the cytoplasmic transport of suitable transcripts by targeting them to the nuclear pore.

TL;DR: A single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types is presented, providing an in-depth analysis of cell type–related gene signatures and transcription factor markers, as as sexual dimorphism, across the whole animal.

TL;DR: It is shown that a single amino acid change converts S.cerevisiae Crm1p from being LMB insensitive to fully LMB sensitive, indicating that Crm 1p is the only relevant LMB target.

TL;DR: It is shown here that Rip1p is essential for the export of heat shock RNAs, and this function is fulfilled by the unique carboxyl terminus of Rip1 p with no substantial contribution from the FG-repeat region.