Vincent Gardeux

TL;DR: The findings that led to this important paradigm shift are summarized and proposed mechanisms for local, proximal, or distal genetic variation-driven variable TF-DNA binding are reviewed.

TL;DR: A single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types is presented, providing an in-depth analysis of cell type–related gene signatures and transcription factor markers, as as sexual dimorphism, across the whole animal.

TL;DR: BRB-seq will transform basic laboratory practice given its capacity to generate genome-wide transcriptomic data at a similar cost as profiling four genes using RT-qPCR, and being up to 25 times cheaper than the standard TruSeq approach.

TL;DR: This Automated Single‐cell Analysis Pipeline (ASAP) combines a wide range of commonly used algorithms with sophisticated visualization tools, and should conceptually be broadly applicable to any RNA‐seq dataset.

TL;DR: Time-resolved transcriptome analysis highlighted a temperature-dependent and virus-specific induction of the IFN-mediated antiviral response in SARS-CoV-2, and provided crucial insight on pivotal virus - host interaction dynamics.