M
Megan van Overbeek
Researcher at Rockefeller University
Publications - 12
Citations - 1673
Megan van Overbeek is an academic researcher from Rockefeller University. The author has contributed to research in topics: Telomere & Shelterin. The author has an hindex of 8, co-authored 11 publications receiving 1477 citations.
Papers
More filters
Journal ArticleDOI
DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks
Megan van Overbeek,Daniel Capurso,Matthew Merrill Carter,Matthew S. Thompson,Elizabeth Frias,Carsten Russ,John S. Reece-Hoyes,Christopher D. Nye,Scott Gradia,Bastien Vidal,Jiashun Zheng,Gregory R. Hoffman,Chris R. Fuller,Andrew May +13 more
TL;DR: This work demonstrates that the pattern of DNA repair following Cas9 cutting at each site is nonrandom and consistent across experimental replicates, cell lines, and reagent delivery methods, and elucidates a strategy for using "error-prone" DNA-repair machinery to generate precise edits.
Journal ArticleDOI
TIN2 Binds TRF1 and TRF2 Simultaneously and Stabilizes the TRF2 Complex on Telomeres
Jeffrey Zheng-Sheng Ye,Jill R. Donigian,Megan van Overbeek,Diego Loayza,Yan Luo,Andrew N. Krutchinsky,Brian T. Chait,Titia de Lange +7 more
TL;DR: The TIN2-mediated cooperative binding of TRF1 and TRF2 to telomeres has important implications for the mechanism of telomere length regulation and protection.
Journal ArticleDOI
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Yong Chen,Yuting Yang,Megan van Overbeek,Jill R. Donigian,Paul Baciu,Titia de Lange,Ming Lei +6 more
TL;DR: This work dissects the interactions of TRF1 and TRF2 with their shared binding partner (TIN2) and other shelterin accessory factors, including Apollo, which interacts with another shelterin-associated factor: PinX1.
Journal ArticleDOI
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal.
TL;DR: The data reveal that HDR at telomeres can take place in the absence of DNA damage foci and underscore the functional compartmentalization within shelterin.
Journal ArticleDOI
Apollo, an artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase
TL;DR: It is proposed that the Artemis-like nuclease Apollo is a shelterin accessory factor required for the protection of telomeres during or after their replication.