M
Meghan C. Naber
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 10
Citations - 1148
Meghan C. Naber is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Adipose tissue & FGF21. The author has an hindex of 7, co-authored 9 publications receiving 854 citations. Previous affiliations of Meghan C. Naber include University of Iowa.
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Journal ArticleDOI
Circulating FGF21 is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
Kathleen R. Markan,Meghan C. Naber,Magdalene Ameka,Maxwell D. Anderegg,David J. Mangelsdorf,Steven A. Kliewer,Moosa Mohammadi,Matthew J. Potthoff +7 more
TL;DR: It is shown that liver-derived FGF21 enters the circulation during fasting but also remains present and functional during the early stage of refeeding, compatible with the concept that FGF 21 functions physiologically as an insulin sensitizer under conditions of acute refeeded and overfeeding.
Journal ArticleDOI
FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver
Stephanie von Holstein-Rathlou,Lucas D. BonDurant,Lila Peltekian,Meghan C. Naber,Terry C. Yin,Kristin E. Claflin,Adriana Ibarra Urizar,Andreas N. Madsen,Cecilia Ratner,Birgitte Holst,Kristian Karstoft,Aurelie Vandenbeuch,Catherine B. Anderson,Martin D. Cassell,Anthony P. Thompson,Thomas P. J. Solomon,Thomas P. J. Solomon,Kamal Rahmouni,Sue C. Kinnamon,Andrew A. Pieper,Matthew P. Gillum,Matthew P. Gillum,Matthew J. Potthoff +22 more
TL;DR: It is concluded that the liver functions to regulate macronutrient-specific intake by producing an endocrine satiety signal that acts centrally to suppress the intake of "sweets."
Journal ArticleDOI
FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms.
Lucas D. BonDurant,Magdalene Ameka,Meghan C. Naber,Kathleen R. Markan,Sharon O. Idiga,Michael R. Acevedo,Susan A. Walsh,David M. Ornitz,Matthew J. Potthoff +8 more
TL;DR: It is found that adiponectin is dispensable for the metabolic effects of FGF 21 in increasing insulin sensitivity and energy expenditure, and FGF21 acutely enhances insulin sensitivity through actions on brown adipose tissue.
Journal ArticleDOI
Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure
Magdalene Ameka,Kathleen R. Markan,Donald A. Morgan,Lucas D. BonDurant,Sharon O. Idiga,Meghan C. Naber,Zhiyong Zhu,Leonid V. Zingman,Leonid V. Zingman,Justin L. Grobe,Kamal Rahmouni,Matthew J. Potthoff +11 more
TL;DR: A previously unrecognized role for FGF21 in the maintenance of body temperature in response to cold is demonstrated, found that only liver-derived FGF 21 enters circulation during acute cold exposure and is critical for thermoregulation.
Journal ArticleDOI
Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice
Jeremy A. Sandgren,Guorui Deng,Danny W Linggonegoro,Sabrina M Scroggins,Katherine J Perschbacher,Anand R. Nair,Taryn E. Nishimura,Shao Yang Zhang,Larry N. Agbor,Jing Wu,Henry L. Keen,Meghan C. Naber,Nicole A Pearson,Kathy Zimmerman,Robert M. Weiss,Noelle C. Bowdler,Yuriy M. Usachev,Donna A. Santillan,Matthew J. Potthoff,Gary L. Pierce,Katherine N. Gibson-Corley,Curt D. Sigmund,Mark K. Santillan,Justin L. Grobe +23 more
TL;DR: It is demonstrated that AVP is sufficient to initiate phenotypes of PE in the absence of placental hypoxia, and it is indicated that a role for AVP may mechanistically contribute to the development of clinical signs ofPE in specific subtypes of human PE.