M
Mehdi Bouhaddou
Researcher at University of California, San Francisco
Publications - 53
Citations - 6111
Mehdi Bouhaddou is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 14, co-authored 39 publications receiving 3610 citations. Previous affiliations of Mehdi Bouhaddou include Gladstone Institutes & Icahn School of Medicine at Mount Sinai.
Papers
More filters
Journal ArticleDOI
Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2
Lucy Thorne,Mehdi Bouhaddou,Ann-Kathrin Barbara Reuschl,Lorena Zuliani-Alvarez,Benjamin J. Polacco,Adrian Pelin,Jyoti Batra,Matthew V. X. Whelan,Myra Hosmillo,Andrea Fossati,Roberta Ragazzini,Irwin Jungreis,Manisha Ummadi,Ajda Rojc,Jane Turner,Marie L. Bischof,Kirsten Obernier,Hannes Braberg,Margaret Soucheray,Alicia L. Richards,Kuei-Ho Chen,Bhavya Harjai,Danish Memon,Joseph Hiatt,Romel Rosales,Brian McGovern,Aminu S Jahun,Jacqueline M. Fabius,Kris M. White,Ian Goodfellow,Yasuyuki Takeuchi,Paola Bonfanti,Kevan M. Shokat,Natalia Jura,Kliment A. Verba,Mahdad Noursadeghi,Pedro Beltrao,Manolis Kellis,Danielle L. Swaney,Adolfo Garcia-Sastre,Clare Jolly,Greg J. Towers,Nevan J. Krogan +42 more
Journal ArticleDOI
Leveraging modeling and simulation to optimize the therapeutic window for epigenetic modifier drugs.
TL;DR: In this article , the authors argue that besides identifying the right responder patient population, the selection of an optimized dosing regimen is equally important, and suggest the combination of efficacy and safety prediction models that capture the quantitative, mechanistic relationships governing the balance between their safety and efficacy dynamics.
Posted ContentDOI
Oncogenic PKA signaling stabilizes MYC oncoproteins via an aurora kinase A-dependent mechanism
Chan Gkl,Chan Gkl,Maisel S,Maisel S,Hwang Yc,Hwang Yc,Wolber Rrb,Wolber Rrb,Phuong Vu,Krushna C. Patra,Mehdi Bouhaddou,Heidi L. Kenerson,Raymond S. Yeung,Danielle L. Swaney,Nevan J. Krogan,Rigney E. Turnham,Rigney E. Turnham,John D. Scott,Kimberly J. Riehle,Nabeel Bardeesy,Gordan Jd,Gordan Jd +21 more
TL;DR: In this paper, the authors define two consensus networks of effectors downstream of PKA in cancer models, one centered on RAS/MAPK components, and a second involves Aurora Kinase A (AURKA).
Posted ContentDOI
Hepatitis C Virus Infects and Perturbs Liver Stem Cells
Nathan L. Meyers,Tal Ashuach,Danielle E Lyons,Camille R. Simoneau,Ann L Erickson,Mehdi Bouhaddou,Thong T. Nguyen,Mir M. Khalid,Taha Y. Taha,Vaishaali Natarajan,Jody L. Baron,Norma Neff,Fabio Zanini,Tokameh Mahmoud,Stephen R. Quake,Nevan J. Krogan,Stewart Cooper,Todd C. McDevitt,Nir Yosef,Nir Yosef,Melanie Ott +20 more
TL;DR: In this article, the authors identify bipotent liver stem cells as novel targets for hepatitis C virus infection and their erroneous differentiation as the potential cause of impaired liver regeneration and cancer development.
Posted ContentDOI
A Simple and Efficient Pipeline for Construction, Merging, Expansion, and Simulation of Large-Scale, Single-Cell Mechanistic Models
Cemal Erdem,Ethan M. Bensman,Mutsuddy A,Michael M. Saint-Antoine,Mehdi Bouhaddou,Robert C. Blake,William B. Dodd,Sean M. Gross,Laura M. Heiser,Feltus Fa,Marc R. Birtwistle +10 more
TL;DR: An open-source pipeline for scalable, single-cell mechanistic modeling from simple, annotated input files that can serve as a foundation for mechanistic data integration as a data integration modality complementary to machine learning is presented.