M
Mehdi Bouhaddou
Researcher at University of California, San Francisco
Publications - 53
Citations - 6111
Mehdi Bouhaddou is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 14, co-authored 39 publications receiving 3610 citations. Previous affiliations of Mehdi Bouhaddou include Gladstone Institutes & Icahn School of Medicine at Mount Sinai.
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Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization
Jose F. Varona,Pedro Landete,Jose A. Lopez-Martin,Vicente Estrada,Vicente Estrada,Roger Paredes,Pablo Guisado-Vasco,Lucia Fernandez de Orueta,Miguel Torralba,Jesús Fortún,Roberto Vates,José Barberán,Bonaventura Clotet,Julio Ancochea,Julio Ancochea,Daniel Carnevali,N. Cabello,Lourdes Porras,Paloma Gijón,Alfonso Monereo,Daniel Abad,Sonia Zuñiga,Isabel Sola,Jordi Rodon,Nuria Izquierdo-Useros,Salvador Fudio,Maria Jose Pontes,Beatriz de Rivas,Patricia Giron de Velasco,Belen Sopesen,Antonio Nieto,Javier Gomez,Pablo Aviles,Rubin Lubomirov,Kris M. White,Romel Rosales,Soner Yildiz,Ann-Kathrin Reuschl,Lucy Thorne,Clare Jolly,Greg J. Towers,Lorena Zuliani-Alvarez,Mehdi Bouhaddou,Kirsten Obernier,Luis Enjuanes,Jose M Fernandez-Sousa,Nevan J. Krogan,Jose Jimeno,Adolfo García-Sastre +48 more
TL;DR: In this article, the effect of Plitidepsin on the antiviral effect of drugs was investigated using a clinical trial conducted by Pharmamar, S.A. and IrsiCaixa (Madrid, Spain).
Posted ContentDOI
Network Reconstruction from Perturbation Time Course Data
Gregory R. Smith,Deepraj Sarmah,Mehdi Bouhaddou,Mehdi Bouhaddou,Alan D Stern,Erskine J,Marc R. Birtwistle +6 more
TL;DR: A dynamic least squares framework is integrated into established modular response analysis (DL-MRA), that specifies sufficient experimental perturbation time course data to robustly infer arbitrary two and three node networks, and gives a rational basis to experimental data requirements for network reconstruction.
Journal ArticleDOI
Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer.
Mehdi Bouhaddou,Rex H. Lee,Hua Li,Neil E. Bhola,Rachel A. O'Keefe,Mohammad Naser,Tian Ran Zhu,Kelechi Nwachuku,Umamaheswar Duvvuri,Adam B. Olshen,Ritu Roy,Aaron Hechmer,Jennifer Bolen,Stephen B. Keysar,Antonio Jimeno,Gordon B. Mills,Scott R. VandenBerg,Danielle L. Swaney,Daniel Johnson,Nevan J. Krogan,Nevan J. Krogan,Nevan J. Krogan,Jennifer R. Grandis +22 more
TL;DR: In this article, the authors applied unbiased hierarchical clustering to reverse-phase protein array molecular profiles from patient-derived xenograft (PDX) tumors and revealed 2 PDX clusters defined by protein networks associated with EGFR inhibitor resistance.
Journal ArticleDOI
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms
G Chan,Samantha Maisel,Y. Christina Hwang,Bryan C Pascual,Rebecca Wolber,Phuong Vu,Krushna C. Patra,Mehdi Bouhaddou,Heidi L. Kenerson,Huat Chye Lim,Donald Long,Raymond S. Yeung,Praveen Sethupathy,Danielle L. Swaney,Nevan J. Krogan,Rigney E. Turnham,Kimberly J. Riehle,John D. Scott,Nabeel Bardeesy,John D. Gordan +19 more
TL;DR: In this paper , the authors used global phosphoproteomics and kinase activity profiling to map conserved signaling outputs driven by a range of genetic changes that activate protein kinase A (PKA) in human cancer.
Posted ContentDOI
Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories
Mehdi Bouhaddou,Ann-Kathrin Barbara Reuschl,Benjamin J. Polacco,Lucy Thorne,Manisha Ummadi,Chengjin Ye,Romel Rosales,Adrian Pelin,Jyoti Batra,Gwendolyn M. Jang,Jiewei Xu,Jack M. Moen,Alicia L. Richards,Yuan Zhou,Bhavya Harjai,Erica Stevenson,Ajda Rojc,Roberta Ragazzini,Matthew V. X. Whelan,Wilhelm Furnon,Giuditta De Lorenzo,Vanessa M. Cowton,Abdullah Muhammad Syed,Alison Ciling,Noa Deutsch,Daniel Pirak,Giulia Dowgier,Dejan Mesner,Jane Turner,Brian McGovern,Mariano Rodriguez,Rocío Leiva-Rebollo,Alistair Dunham,Xiaofang Zhong,Manon Eckhardt,Andrea Fossati,Nicholas O. Liotta,Thomas Kehrer,Anastasija Cupic,Magdalena Rutkowska,na Jaime García Mena,Sadaf Aslam,Alyssa Hoffert,Hélène Foussard,John Pham,Molly C. Lyons,Laura Jean Donahue,Aliesha Griffin,Rebecca L. Nugent,Kevin Holden,Rob Deans,Pablo Aviles,Jose A. Lopez-Martin,Jose Jimeno,Kirsten Obernier,Jacqueline M. Fabius,Margaret Soucheray,Ruth Hüttenhain,Irwin Jungreis,Manolis Kellis,Ignacia Echeverria,Kliment A. Verba,Paola Bonfanti,Pedro Beltrao,Roded Sharan,Jennifer A. Doudna,Luis Martinez-Sobrido,Arvind H. Patel,Massimo Palmarini,Lisa Miorin,Kris M. White,Danielle L. Swaney,Adolfo Garcia-Sastre,Clare Jolly,Lorena Zuliani-Alvarez,Greg J. Towers,Nevan J. Krogan +76 more
TL;DR: How VOCs have evolved to fine-tune viral protein expression and protein-protein interactions to evade both innate and adaptive immune responses is described, offering a likely explanation for increased transmission in humans.