M
Mehdi Bouhaddou
Researcher at University of California, San Francisco
Publications - 53
Citations - 6111
Mehdi Bouhaddou is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 14, co-authored 39 publications receiving 3610 citations. Previous affiliations of Mehdi Bouhaddou include Gladstone Institutes & Icahn School of Medicine at Mount Sinai.
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Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses
Ruofan Wang,Camille R. Simoneau,Jessie Kulsuptrakul,Mehdi Bouhaddou,Katherine A. Travisano,Jennifer M. Hayashi,Jared Carlson-Stevermer,Jennifer Oki,Kevin Holden,Nevan J. Krogan,Melanie Ott,Andreas S. Puschnik +11 more
TL;DR: Parallel genome-wide CRISPR screens in cells infected by SARS-CoV-2 as well as two seasonally circulating common cold coronaviruses are conducted, finding phosphatidylinositol phosphate biosynthesis and cholesterol homeostasis as critical host pathways supporting infection by all three coronviruses.
Journal ArticleDOI
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Danielle L. Swaney,Dana J. Ramms,Zhiyong Wang,Jisoo Park,Yusuke Goto,Margaret Soucheray,Neil E. Bhola,Kyumin Kim,Fan Zheng,Yan Zeng,Michael J. McGregor,Kari A. Herrington,Rachel A. O'Keefe,Nan Jin,Nathan K. VanLandingham,Helene Foussard,John Von Dollen,Mehdi Bouhaddou,David Jimenez-Morales,Kirsten Obernier,Jason F. Kreisberg,Min-Kyu Kim,Daniel Johnson,Natalia Jura,Jennifer R. Grandis,J. Silvio Gutkind,Trey Ideker,Nevan J. Krogan +27 more
TL;DR: In this article, a framework for elucidating tumor genetic complexity through multidimensional protein-protein interaction maps and applying it to enhancing our understanding of head and neck squamous cell was proposed.
Journal ArticleDOI
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
J.F. Varona,Pedro Landete,Jose A. Lopez-Martin,Vicente Estrada,Roger Paredes,Pablo Guisado-Vasco,L. Fernández de Orueta,Miguel Torralba,Jesús Fortún,R. Vates,José Barberán,Bonaventura Clotet,Julio Ancochea,Daniela Candia Carnevali,Noemi Cabello,L Porras,Paloma Gijón,Alfonso Monereo,Daniel Abad,Sonia Zuñiga,Isabel Sola,Jordi Rodon,Júlia Vergara-Alert,Nuria Izquierdo-Useros,Salvador Fudio,Maria J. S. L. Pontes,Beatriz de Rivas,Patricia Girón de Velasco,Antonio Nieto,Javier Gomez,Pablo Aviles,Rubin Lubomirov,Alvaro Belgrano,Belén Sopesén,Kris M. White,Romel Rosales,Soner Yildiz,Ann-Kathrin Barbara Reuschl,Lucy Thorne,Clare Jolly,Greg J. Towers,Lorena Zuliani-Alvarez,Mehdi Bouhaddou,Kirsten Obernier,Brian McGovern,Mariano Rodriguez,Luis Enjuanes,J. M. Fernández-Sousa,Nevan J. Krogan,Jose Jimeno,Adolfo García-Sastre +50 more
TL;DR: It is shown that plitidepsin distributes preferentially to lung over plasma, with similar potency against across several SARS-CoV-2 variants in preclinical studies, and has a favorable safety profile in patients with COVID-19.
Journal ArticleDOI
A functional map of HIV-host interactions in primary human T cells
Joseph Hiatt,Judd F. Hultquist,Michael McGregor,Mehdi Bouhaddou,Ryan T. Leenay,Lacy M Simons,Janet M. Young,Paige Haas,Theodore L. Roth,Victoria Tobin,Jason A. Wojcechowskyj,Jonathan M. Woo,Ujjwal Rathore,Devin A. Cavero,Eric Shifrut,Thong T. Nguyen,Kelsey M. Haas,Harmit S. Malik,Jennifer A. Doudna,Andrew P. May,Alexander Marson,Nevan J. Krogan +21 more
TL;DR: In this paper , the authors target 426 genes previously implicated in the HIV lifecycle through protein interaction studies for CRISPR-Cas9-mediated knockout in primary human CD4+ T cells in order to systematically assess their functional roles in HIV replication.
Journal ArticleDOI
Integrating Transcriptomic Data with Mechanistic Systems Pharmacology Models for Virtual Drug Combination Trials
TL;DR: A simulation-based approach that integrates patient-specific data with a mechanistic computational model of pan-cancer driver pathways to prioritize drug combinations by their simulated effects on tumor cell proliferation and death is built.