Clare Jolly

TL;DR: It is proposed that HIV-1 can spread using nanotubular connections formed by short-term intercellular unions in which T cells specialize, and an extracellular matrix scaffold allows T-cell nanotubes to adopt variably shaped contours.

TL;DR: It is proposed that receptor engagement by Env directs the rapid, actin-dependent recruitment of HIV receptors and adhesion molecules to the interface, resulting in a stable adhesive junction across which HIV infects the target cell.

TL;DR: It is shown that copy number variants (CNVs) show a variety of genetic signals consistent with rapid turnover and make substantial contributions to quantitative traits, most notably intracellular amino acid concentrations, growth under stress and sugar utilization in winemaking, whereas rearrangements are strongly associated with reproductive isolation.

TL;DR: This review summarises the current knowledge concerning virological synapses induced by retroviruses and indicates that cell–cell viral dissemination appears to function by triggering existing cellular pathways involved in antigen presentation and T‐cell communication.

TL;DR: It is proposed that HIV-1 requires both actin and tubulin components of the T-cell cytoskeleton to direct its assembly and budding and to elaborate a functional VS.