M
Mei Hong
Researcher at University of Texas Southwestern Medical Center
Publications - 3
Citations - 3080
Mei Hong is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: IκB kinase & MAP kinase kinase kinase. The author has an hindex of 3, co-authored 3 publications receiving 2891 citations. Previous affiliations of Mei Hong include University of Texas at Dallas.
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Journal ArticleDOI
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
TL;DR: The purification and identification of TRIKA2, which is composed of TAK1, TAB1 and TAB2, a protein kinase complex previously implicated in IKK activation through an unknown mechanism, indicate that ubiquitination has an important regulatory role in stress response pathways, including those of IKK and JNK.
Journal ArticleDOI
TAB2 and TAB3 Activate the NF-κB Pathway through Binding to Polyubiquitin Chains
Atsuhiro Kanayama,Rashu B. Seth,Lijun Sun,Chee Kwee Ea,Mei Hong,Abdullah Shaito,Yu Hsin Chiu,Li Deng,Zhijian J. Chen +8 more
TL;DR: Evidence is presented that TAB2 and TAB3 are receptors that bind preferentially to lysine 63-linked polyubiquitin chains through a highly conserved zinc finger (ZnF) domain, which indicates that polyubanquitin binding domains represent a new class of signaling domains that regulate protein kinase activity through a nonproteolytic mechanism.
Journal ArticleDOI
The Role of Ubiquitination in Drosophila Innate Immunity
Rui Zhou,Neal S. Silverman,Neal S. Silverman,Mei Hong,Dorothy S. Liao,Yvonne Chung,Zhijian J. Chen,Tom Maniatis +7 more
TL;DR: Surprisingly, it is found that the Drosophila caspase DREDD and its partner dFADD are required for the activation of DmIKK and JNK, in addition to their role in Relish cleavage, which reveals an evolutionarily conserved role of ubiquitination in IKK activation.