J
Jun-ichiro Inoue
Researcher at University of Tokyo
Publications - 238
Citations - 23727
Jun-ichiro Inoue is an academic researcher from University of Tokyo. The author has contributed to research in topics: Signal transduction & Gene. The author has an hindex of 68, co-authored 227 publications receiving 22158 citations. Previous affiliations of Jun-ichiro Inoue include University of Tokushima & National Institutes of Health.
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Journal ArticleDOI
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.
Hiroshi Takayanagi,Sunhwa Kim,Takako Koga,Takako Koga,Hiroshi Nishina,Masashi Isshiki,Hiroki Yoshida,Hiroki Yoshida,Akio Saiura,Miho Isobe,Miho Isobe,Taeko Yokochi,Jun-ichiro Inoue,Erwin F. Wagner,Tak W. Mak,Tatsuhiko Kodama,Tadatsugu Taniguchi +16 more
TL;DR: RANKL selectively induces NFATc1 expression via TRAF6 and c-Fos signaling pathways, and may represent a master switch for regulating terminal differentiation of osteoclasts, functioning downstream of RANKL.
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TAK1 is a ubiquitin-dependent kinase of MKK and IKK
TL;DR: The purification and identification of TRIKA2, which is composed of TAK1, TAB1 and TAB2, a protein kinase complex previously implicated in IKK activation through an unknown mechanism, indicate that ubiquitination has an important regulatory role in stress response pathways, including those of IKK and JNK.
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The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
Jun Ninomiya-Tsuji,Kazuya Kishimoto,Atsushi Hiyama,Jun-ichiro Inoue,Zhaodan Cao,Kunihiro Matsumoto +5 more
TL;DR: It is shown that the MAPKK kinase TAK1 acts upstream of NIK in the IL-1-activated signalling pathway and that TAK 1 associates with TRAF6 during IL- 1 signalling, which indicates that Taker1 links TRAf6 to the NIK–IKK cascade in theIL-1 signalling pathway.
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Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes.
Taro Kawai,Osamu Takeuchi,Takashi Fujita,Jun-ichiro Inoue,Peter F. Mühlradt,Shintaro Sato,Katsuaki Hoshino,Shizuo Akira +7 more
TL;DR: The characterization of the MyD88-independent pathway via TLR4 is reported, a MyD 88-dependent pathway that is critical to the induction of inflammatory cytokines and a Myd88/TNFR-associated factor 6- independent pathway that regulates induction of IP-10.
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Interferon-|[alpha]| induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
Taro Kawai,Shintaro Sato,Ken Ishii,Cevayir Coban,Hiroaki Hemmi,Masahiro Yamamoto,Kenta Terai,Michiyuki Matsuda,Jun-ichiro Inoue,Satoshi Uematsu,Osamu Takeuchi,Shizuo Akira +11 more
TL;DR: It is shown that TLR-mediated IFN-α induction requires the formation of a complex consisting of MyD88, TRAF6 and IRF7 as well as TRAF 6-dependent ubiquitination.