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Chee Kwee Ea
Researcher at University of Malaya
Publications - 22
Citations - 6660
Chee Kwee Ea is an academic researcher from University of Malaya. The author has contributed to research in topics: Regulation of gene expression & Ubiquitin ligase. The author has an hindex of 14, co-authored 20 publications receiving 6026 citations. Previous affiliations of Chee Kwee Ea include California Institute of Technology & National Taiwan University.
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Journal ArticleDOI
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
TL;DR: The identification of a novel protein termed MAVS (mitochondrial antiviral signaling), which mediates the activation of NF-kappaB and IRF 3 in response to viral infection, and implicates a new role of mitochondria in innate immunity.
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Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO
TL;DR: The results reveal the biochemical mechanism underlying the essential signaling function of NEMO and provide direct evidence that signal-induced site-specific ubiquitination of RIP1 is required for IKK activation.
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TAB2 and TAB3 Activate the NF-κB Pathway through Binding to Polyubiquitin Chains
Atsuhiro Kanayama,Rashu B. Seth,Lijun Sun,Chee Kwee Ea,Mei Hong,Abdullah Shaito,Yu Hsin Chiu,Li Deng,Zhijian J. Chen +8 more
TL;DR: Evidence is presented that TAB2 and TAB3 are receptors that bind preferentially to lysine 63-linked polyubiquitin chains through a highly conserved zinc finger (ZnF) domain, which indicates that polyubanquitin binding domains represent a new class of signaling domains that regulate protein kinase activity through a nonproteolytic mechanism.
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The TRAF6 Ubiquitin Ligase and TAK1 Kinase Mediate IKK Activation by BCL10 and MALT1 in T Lymphocytes
TL;DR: Evidence is presented that TRAF6 ubiquitin ligase and TAK1 protein kinase mediate IKK activation by BCL10 and MALT1, and a small fraction of these proteins form high molecular weight oligomers, which culminates in NF-kappaB activation in T lymphocytes.
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miR-146a controls the resolution of T cell responses in mice
Lili Yang,Mark Boldin,Yang Yu,Claret Siyuan Liu,Chee Kwee Ea,Parameswaran Ramakrishnan,Konstantin Taganov,Jimmy L. Zhao,David Baltimore +8 more
TL;DR: By suppressing expression of TRAF6 and IRAK1, miR-146a regulates NF-κB activation in T cells through a negative feedback loop and controls the resolution of T cell responses in mice.