M
Meirav Pevsner-Fischer
Researcher at Weizmann Institute of Science
Publications - 55
Citations - 9838
Meirav Pevsner-Fischer is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Mesenchymal stem cell & Stromal cell. The author has an hindex of 28, co-authored 53 publications receiving 7124 citations.
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Journal ArticleDOI
Personalized Nutrition by Prediction of Glycemic Responses
David Zeevi,Tal Korem,Niv Zmora,Niv Zmora,David Israeli,Daphna Rothschild,Adina Weinberger,Orly Ben-Yacov,Dar Lador,Tali Avnit-Sagi,Maya Lotan-Pompan,Jotham Suez,Jemal Ali Mahdi,Elad Matot,Gal Malka,Noa Kosower,Michal Rein,Gili Zilberman-Schapira,Lenka Dohnalová,Meirav Pevsner-Fischer,Rony Bikovsky,Zamir Halpern,Eran Elinav,Eran Segal +23 more
TL;DR: A machine-learning algorithm is devised that integrates blood parameters, dietary habits, anthropometrics, physical activity, and gut microbiota measured in an 800-person cohort and shows that it accurately predicts personalized postprandial glycemic response to real-life meals, and a blinded randomized controlled dietary intervention based on this algorithm resulted in significantly lower postpr andial responses and consistent alterations to gut microbiota configuration.
Journal ArticleDOI
Environment dominates over host genetics in shaping human gut microbiota
Daphna Rothschild,Omer Weissbrod,Elad Barkan,Alexander Kurilshikov,Tal Korem,David Zeevi,Paul I. Costea,Anastasia Godneva,Iris N. Kalka,Noam Bar,Smadar Shilo,Dar Lador,Arnau Vich Vila,Niv Zmora,Niv Zmora,Meirav Pevsner-Fischer,David Israeli,Noa Kosower,Gal Malka,Bat Chen Wolf,Tali Avnit-Sagi,Maya Lotan-Pompan,Adina Weinberger,Zamir Halpern,Shai Carmi,Jingyuan Fu,Cisca Wijmenga,Cisca Wijmenga,Alexandra Zhernakova,Eran Elinav,Eran Segal +30 more
TL;DR: Genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment are examined, and it is demonstrated that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition.
Journal ArticleDOI
Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features
Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Jotham Suez,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Eran Kotler,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Yotam Cohen,Raquel Linevsky,Daphna Rothschild,Andreas E. Moor,Shani Ben-Moshe,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Hagit Shapiro,Meirav Pevsner-Fischer,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: The metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome, indicating that empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa.
Journal ArticleDOI
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.
Maayan Levy,Christoph A. Thaiss,David Zeevi,Lenka Dohnalová,Gili Zilberman-Schapira,Jemal Ali Mahdi,Eyal David,Alon Savidor,Tal Korem,Yonatan Herzig,Meirav Pevsner-Fischer,Hagit Shapiro,Anette Christ,Alon Harmelin,Zamir Halpern,Eicke Latz,Eicke Latz,Richard A. Flavell,Ido Amit,Eran Segal,Eran Elinav +20 more
TL;DR: It is demonstrated that the microbiota-associated metabolites taurine, histamine, and spermine shape the host-microbiome interface by co-modulating NLRP6 inflammasome signaling, epithelial IL-18 secretion, and downstream anti-microbial peptide (AMP) profiles.
Journal ArticleDOI
Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT.
Jotham Suez,Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Max Horn,Yotam Cohen,Andreas E. Moor,David Zeevi,Tal Korem,Eran Kotler,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Meirav Pevsner-Fischer,Hagit Shapiro,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: Collectively, potential post-antibiotic probiotic benefits may be offset by a compromised gut mucosal recovery, highlighting a need of developing aFMT or personalized probiotic approaches achieving mucosal protection without compromising microbiome recolonization in the antibiotics-perturbed host.