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Itai Sharon
Researcher at Tel-Hai Academic College
Publications - 75
Citations - 9615
Itai Sharon is an academic researcher from Tel-Hai Academic College. The author has contributed to research in topics: Metagenomics & Medicine. The author has an hindex of 36, co-authored 60 publications receiving 7678 citations. Previous affiliations of Itai Sharon include Planetary Science Institute & Technion – Israel Institute of Technology.
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Journal ArticleDOI
Unusual biology across a group comprising more than 15% of domain Bacteria
Christopher T. Brown,Laura A. Hug,Brian C. Thomas,Itai Sharon,Cindy J. Castelle,Andrea Singh,Michael J. Wilkins,Kelly C. Wrighton,Kenneth H. Williams,Jillian F. Banfield +9 more
TL;DR: This work reconstructed 8 complete and 789 draft genomes from bacteria representing >35 phyla and documented features that consistently distinguish these organisms from other bacteria, infer that this group, which may comprise >15% of the bacterial domain, has shared evolutionary history, and describe it as the candidate phyla radiation (CPR).
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Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features
Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Jotham Suez,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Eran Kotler,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Yotam Cohen,Raquel Linevsky,Daphna Rothschild,Andreas E. Moor,Shani Ben-Moshe,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Hagit Shapiro,Meirav Pevsner-Fischer,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: The metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome, indicating that empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa.
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Thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system
Karthik Anantharaman,Christopher T. Brown,Laura A. Hug,Itai Sharon,Cindy J. Castelle,Alexander J. Probst,Brian C. Thomas,Andrea Singh,Michael J. Wilkins,Ulas Karaoz,Eoin L. Brodie,Kenneth H. Williams,Susan S. Hubbard,Jillian F. Banfield,Jillian F. Banfield +14 more
TL;DR: Terabase-scale cultivation-independent metagenomics is applied to aquifer sediments and groundwater and 2,540 draft-quality, near-complete and complete strain-resolved genomes are reconstructed, finding that few organisms within the community can conduct multiple sequential redox transformations.
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Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT.
Jotham Suez,Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Max Horn,Yotam Cohen,Andreas E. Moor,David Zeevi,Tal Korem,Eran Kotler,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Meirav Pevsner-Fischer,Hagit Shapiro,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: Collectively, potential post-antibiotic probiotic benefits may be offset by a compromised gut mucosal recovery, highlighting a need of developing aFMT or personalized probiotic approaches achieving mucosal protection without compromising microbiome recolonization in the antibiotics-perturbed host.
Journal ArticleDOI
Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated bacterial phyla.
Kelly C. Wrighton,Brian C. Thomas,Itai Sharon,Christopher S. Miller,Cindy J. Castelle,Nathan C Verberkmoes,Michael J. Wilkins,Robert L. Hettich,Mary S. Lipton,Kenneth H. Williams,Philip E. Long,Jillian F. Banfield,Jillian F. Banfield +12 more
TL;DR: This article uncovered metabolic characteristics for members of these phyla, and a new lineage, PER, via cultivation-independent recovery of 49 partial to near-complete genomes from an acetate-amended aquifer.