M
Melek N. Ucisik
Researcher at Baylor College of Medicine
Publications - 23
Citations - 451
Melek N. Ucisik is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: DNA & Polymerase. The author has an hindex of 13, co-authored 22 publications receiving 316 citations. Previous affiliations of Melek N. Ucisik include University of Florida & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Insight into the cation-π interaction at the metal binding site of the copper metallochaperone CusF.
TL;DR: Quantum-mechanical calculations showed that Cu(+) binds in a distorted tetrahedral coordination environment in the Trp44Met mutant, which lacks the cation-π interaction.
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C-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis.
Ying-Chu Chen,John C. Faver,Angela F. Ku,Gabriella Miklossy,Kevin Riehle,Kurt M. Bohren,Melek N. Ucisik,Martin M. Matzuk,Zhifeng Yu,Nicholas Simmons +9 more
TL;DR: Conditions utilizing an N-heterocyclic carbene–palladium catalyst are developed that extends this reaction to the coupling of DNA-conjugated (hetero)aromatic chlorides with (heterO)ar automatic and select aliphatic amine nucleophiles to build a 63 million-membered DECL.
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Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library.
Surendra Dawadi,Nicholas Simmons,Gabriella Miklossy,Kurt M. Bohren,John C. Faver,Melek N. Ucisik,Pranavanand Nyshadham,Zhifeng Yu,Martin M. Matzuk +8 more
TL;DR: A protease-focused DNA-encoded chemical library was designed that utilizes chemotypes known to engage conserved catalytic protease residues, and a DNA-compatible method for guanidinylation of amines and reduction of nitriles is developed.
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Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
Zhifeng Yu,Angela F. Ku,Justin L. Anglin,Rajesh Sharma,Melek N. Ucisik,John C. Faver,Feng Li,Pranavanand Nyshadham,Nicholas Simmons,Kiran L. Sharma,Sureshbabu Nagarajan,Kevin Riehle,Gundeep Kaur,Banumathi Sankaran,Marta Storl-Desmond,Stephen Palmer,Damian W. Young,Choel Kim,Martin M. Matzuk +18 more
TL;DR: In this paper, a collection of DNA-encoded chemical libraries for BRBD-BD1 and BRDT-BD2 binders was screened and high enrichment hits were identified and resynthesized off-DNA and examined for their ability to compete with JQ1 in BRDT and BRD4 bromodomain AlphaScreen assays.
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Molecular Dynamics Study of Twister Ribozyme: Role of Mg2+ Ions and the Hydrogen-Bonding Network in the Active Site
TL;DR: Molecular dynamics simulations of the env22 twister ribozyme are performed to elucidate the structural and equilibrium dynamical properties, as well as to examine the role of Mg2+ ions and possible candidates for the general base and acid in the self-cleavage mechanism.