N
Nicholas Simmons
Researcher at Baylor College of Medicine
Publications - 29
Citations - 776
Nicholas Simmons is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Aryl & Catalysis. The author has an hindex of 12, co-authored 25 publications receiving 576 citations. Previous affiliations of Nicholas Simmons include Janssen Pharmaceutica & University of Pennsylvania.
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Journal ArticleDOI
Enantioselective Dichlorination of Allylic Alcohols
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Nicholas Simmons,Nicholas Simmons,Yongcheng Ying,Yongcheng Ying,Philipp Heretsch,Philipp Heretsch,Jason S. Chen,Jason S. Chen +9 more
TL;DR: The development of an enantioselective allylic alcohol dichlorination catalyzed by dimeric cinchona alkaloid derivatives and employing aryl iododichlorides as chlorine sources is reported.
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Carbonylative Cross-Coupling of ortho-Disubstituted Aryl Iodides. Convenient Synthesis of Sterically Hindered Aryl Ketones
TL;DR: A mild and general protocol for the carbonylative cross-coupling of sterically hindered ortho-disubstituted aryl iodides is reported, which provides an array of substituted biaryl ketones in modest to excellent yield.
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A Mild, DNA-Compatible Nitro Reduction Using B 2 (OH) 4
Huang-Chi Du,Nicholas Simmons,John C. Faver,Zhifeng Yu,Murugesan Palaniappan,Kevin Riehle,Martin M. Matzuk +6 more
TL;DR: A hypodiboric acid system for the reduction of nitro groups on DNA–chemical conjugates has been developed and provided good to excellent yields of the reduced amine product for a variety of functionalized aromatic, heterocyclic, and aliphatic nitro compounds.
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Quantitative Comparison of Enrichment from DNA-Encoded Chemical Library Selections.
John C. Faver,Kevin Riehle,David R. Lancia,Jared B. J. Milbank,Christopher S. Kollmann,Nicholas Simmons,Zhifeng Yu,Martin M. Matzuk +7 more
TL;DR: A normalized z-score enrichment metric is proposed using a binomial distribution model that satisfies important criteria that are relevant for analysis of DEL selection data and allows for quantitative comparisons of enrichment of n-synthons from parallel DEL selections.
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C-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis.
Ying-Chu Chen,John C. Faver,Angela F. Ku,Gabriella Miklossy,Kevin Riehle,Kurt M. Bohren,Melek N. Ucisik,Martin M. Matzuk,Zhifeng Yu,Nicholas Simmons +9 more
TL;DR: Conditions utilizing an N-heterocyclic carbene–palladium catalyst are developed that extends this reaction to the coupling of DNA-conjugated (hetero)aromatic chlorides with (heterO)ar automatic and select aliphatic amine nucleophiles to build a 63 million-membered DECL.