R
Rajesh Sharma
Researcher at Baylor College of Medicine
Publications - 18
Citations - 300
Rajesh Sharma is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Capsid & Virus. The author has an hindex of 7, co-authored 18 publications receiving 174 citations. Previous affiliations of Rajesh Sharma include Indian Institute of Technology Roorkee.
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Journal ArticleDOI
Inhibition of chikungunya virus by picolinate that targets viral capsid protein.
Rajesh Sharma,Benazir Fatma,Amrita Saha,Sailesh Bajpai,Srinivas Sistla,Paban Kumar Dash,Manmohan Parida,Pravindra Kumar,Shailly Tomar +8 more
TL;DR: The binding of picolinic acid (PCA) to the conserved hydrophobic pocket of capsid protein was analyzed and may serve as the basis for the development of PCA based drugs against alphaviral diseases.
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Kinetic characterization of trans-proteolytic activity of Chikungunya virus capsid protease and development of a FRET-based HTS assay.
TL;DR: The availability of active recombinant CVCP and cost effective fluorogenic peptide based in vitro FRET assay may serve as the basis for therapeutics development against CHIKV.
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Structure-function insights into chikungunya virus capsid protein: Small molecules targeting capsid hydrophobic pocket.
TL;DR: Structuring of chikungunya virus capsid protease domain reveals a chymotrypsin-like protease fold with a conserved hydrophobic pocket in CHIKV capsid protein (CP) for interaction with the cytoplasmic tail of E2 (cdE2) similar to the capsidprotein of other alphaviruses.
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Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
Zhifeng Yu,Angela F. Ku,Justin L. Anglin,Rajesh Sharma,Melek N. Ucisik,John C. Faver,Feng Li,Pranavanand Nyshadham,Nicholas Simmons,Kiran L. Sharma,Sureshbabu Nagarajan,Kevin Riehle,Gundeep Kaur,Banumathi Sankaran,Marta Storl-Desmond,Stephen Palmer,Damian W. Young,Choel Kim,Martin M. Matzuk +18 more
TL;DR: In this paper, a collection of DNA-encoded chemical libraries for BRBD-BD1 and BRDT-BD2 binders was screened and high enrichment hits were identified and resynthesized off-DNA and examined for their ability to compete with JQ1 in BRDT and BRD4 bromodomain AlphaScreen assays.
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Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization.
Rajesh Sharma,Kyoung-Jae Choi,My Diem Quan,Sonum Sharma,Banumathi Sankaran,Hyekyung Park,Anel LaGrone,Jean J Kim,Kevin R. MacKenzie,Allan Chris M. Ferreon,Choel Kim,Josephine C. Ferreon +11 more
TL;DR: In this paper, the authors show that the reprogramming factor KLF4 undergoes biomolecular condensation even in the absence of its intrinsically disordered region, and propose a mechanism for selectively organizing and re-organizing the genome based on the local sequence and epigenetic state.