M
Melika Ben Ahmed
Researcher at Pasteur Institute
Publications - 56
Citations - 1288
Melika Ben Ahmed is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Medicine & Leishmania major. The author has an hindex of 14, co-authored 44 publications receiving 1116 citations. Previous affiliations of Melika Ben Ahmed include Tunis El Manar University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease.
Jean-Jacques Mention,Melika Ben Ahmed,Bernadette Bègue,Ullah Barbe,Virginie Verkarre,Virginie Verkarre,Vahid Asnafi,Jean-Frederic Colombel,Paul Henri Cugnenc,Frank M. Ruemmele,Elisabeth Mcintyre,Nicole Brousse,Nicole Brousse,Chistophe Cellier,Nadine Cerf-Bensussan +14 more
TL;DR: Data provide strong evidence that uncontrolled overexpression of IL-15 in refractory celiac sprue perpetuates epithelial damage and promotes the emergence of T-cell clonal proliferations.
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IL-15 Renders Conventional Lymphocytes Resistant to Suppressive Functions of Regulatory T Cells through Activation of the Phosphatidylinositol 3-Kinase Pathway
Melika Ben Ahmed,Nadia Belhadj Hmida,Nicolette Moes,Sophie Buyse,Maha Abdeladhim,Hechmi Louzir,Nadine Cerf-Bensussan +6 more
TL;DR: The data point to the ambiguous role of IL-15 in the control of Treg functions, which may be instrumental to mount rapid but transient proinflammatory immune responses against pathogens but may become deleterious in situations associated with protracted IL- 15 over-expression.
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Impaired Control of Effector T Cells by Regulatory T Cells: A Clue to Loss of Oral Tolerance and Autoimmunity in Celiac Disease?
Nadia Belhadj Hmida,Melika Ben Ahmed,Amel Moussa,Majd Ben Rejeb,Yosra Said,Nadia Kourda,Bertrand Meresse,Maha Abdeladhim,Hechmi Louzir,Nadine Cerf-Bensussan +9 more
TL;DR: The results indicate that effector T lymphocytes from active CD become resistant to suppression by Tregs, which might cause loss of tolerance to gluten, but also to self-antigens.
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Characterization of the antibody response to the saliva of Phlebotomus papatasi in people living in endemic areas of cutaneous leishmaniasis.
Soumaya Marzouki,Melika Ben Ahmed,Thouraya Boussoffara,Maha Abdeladhim,Nissaf Ben Aleya-Bouafif,Abdelkader Namane,Nabil Bel Haj Hamida,Afif Ben Salah,Hechmi Louzir +8 more
TL;DR: Important data obtained in mice raise the possibility that immunization against the saliva of sand flies could protect from leishmaniasis, and immunoproteomic analyses may help to identify the impact of each salivary protein on the L. major infection and to select potential vaccine candidates.
Journal ArticleDOI
Salivary Antigen SP32 Is the Immunodominant Target of the Antibody Response to Phlebotomus papatasi Bites in Humans
Soumaya Marzouki,Maha Abdeladhim,Chaouki Ben Abdessalem,Fabiano Oliveira,Beya Ferjani,Dana C. Gilmore,Hechmi Louzir,Hechmi Louzir,Jesus G. Valenzuela,Melika Ben Ahmed,Melika Ben Ahmed +10 more
TL;DR: These findings demonstrate that PpSP32 is the immunodominant target of the antibody response to P. papatasi bites and represents a good candidate for large scale testing of human exposure to the vector and perhaps for assessing the risk of contracting the disease.