J
Jean-Jacques Mention
Researcher at French Institute of Health and Medical Research
Publications - 15
Citations - 2983
Jean-Jacques Mention is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Intraepithelial lymphocyte & Immune system. The author has an hindex of 12, co-authored 15 publications receiving 2760 citations. Previous affiliations of Jean-Jacques Mention include Pasteur Institute & Necker-Enfants Malades Hospital.
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Journal ArticleDOI
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense.
Naoko Satoh-Takayama,Christian A. J. Vosshenrich,Christian A. J. Vosshenrich,Sarah Lesjean-Pottier,Sarah Lesjean-Pottier,Shinichiro Sawa,Matthias Lochner,Frederique Rattis,Jean-Jacques Mention,Jean-Jacques Mention,Kader Thiam,Nadine Cerf-Bensussan,Ofer Mandelboim,Gérard Eberl,James P. Di Santo,James P. Di Santo +15 more
TL;DR: RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces.
Journal ArticleDOI
A Direct Role for NKG2D/MICA Interaction in Villous Atrophy during Celiac Disease
Sophie Hue,Jean-Jacques Mention,Renato C. Monteiro,Shao Ling Zhang,Christophe Cellier,Jacques Schmitz,Virginie Verkarre,Nassima Fodil,Seiamak Bahram,Nadine Cerf-Bensussan,Sophie Caillat-Zucman +10 more
TL;DR: It is shown that MICA is strongly expressed at epithelial cell surface in patients with active disease and is induced by gliadin or its p31-49 derived peptide upon in vitro challenge, which supports a key role for MIC/NKG2D in the activation of intraepithelial immunity in response to danger.
Journal ArticleDOI
Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease.
Jean-Jacques Mention,Melika Ben Ahmed,Bernadette Bègue,Ullah Barbe,Virginie Verkarre,Virginie Verkarre,Vahid Asnafi,Jean-Frederic Colombel,Paul Henri Cugnenc,Frank M. Ruemmele,Elisabeth Mcintyre,Nicole Brousse,Nicole Brousse,Chistophe Cellier,Nadine Cerf-Bensussan +14 more
TL;DR: Data provide strong evidence that uncontrolled overexpression of IL-15 in refractory celiac sprue perpetuates epithelial damage and promotes the emergence of T-cell clonal proliferations.
Journal ArticleDOI
IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease–associated inflammation and lymphomagenesis
Georgia Malamut,Raja El Machhour,Nicolas Montcuquet,Séverine Martin-Lannerée,Isabelle Dusanter-Fourt,Virginie Verkarre,Jean-Jacques Mention,Gabriel Rahmi,Hiroshi Kiyono,Eric A. Butz,Nicole Brousse,Christophe Cellier,Nadine Cerf-Bensussan,Bertrand Meresse +13 more
TL;DR: It is shown that the survival signals delivered by IL-15 to freshly isolated human IELs and to human Iel cell lines derived from CD patients with type II refractory CD - a clinicopathological entity considered an intermediary step between CD and enteropathy-associated T cell lymphoma - depend on the antiapoptotic factors Bcl-2 and/or Bcl
Journal ArticleDOI
Inhibition of TGF-β Signaling by IL-15: A New Role for IL-15 in the Loss of Immune Homeostasis in Celiac Disease
Mélika Benahmed,Mélika Benahmed,Bertrand Meresse,Bertrand Meresse,Bertrand Arnulf,Bertrand Arnulf,Bertrand Arnulf,Ullah Barbe,Ullah Barbe,Jean-Jacques Mention,Jean-Jacques Mention,Virginie Verkarre,Virginie Verkarre,Virginie Verkarre,Matthieu Allez,Christophe Cellier,Christophe Cellier,Olivier Hermine,Olivier Hermine,Olivier Hermine,Nadine Cerf–Bensussan,Nadine Cerf–Bensussan +21 more
TL;DR: Impairment of TGF-beta-mediated signaling by IL-15 might promote and sustain intestinal inflammation in celiac disease, and this data provide a new rationale for the potent proinflammatory effects ofIL-15, and further support the concept that IL- 15 is a meaningful therapeutic target in inflammatory diseases associated with irreducible elevation of Il-15.