R
Robyn Roth
Researcher at Washington University in St. Louis
Publications - 83
Citations - 10516
Robyn Roth is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Cytoplasm & Thallus. The author has an hindex of 40, co-authored 80 publications receiving 9426 citations.
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Journal ArticleDOI
Role of Escherichia coli Curli Operons in Directing Amyloid Fiber Formation
Matthew George Chapman,Lloyd S. Robinson,Jerome S. Pinkner,Robyn Roth,John E. Heuser,Mårten Hammar,Staffan Normark,Scott J. Hultgren +7 more
TL;DR: Biochemical, biophysical, and imaging analyses revealed that fibers produced by Escherichia coli called curli were amyloid, and curli biogenesis was dependent on the nucleation-precipitation machinery requiring the CsgE and CsgF chaperone-like and nucleator proteins, respectively.
Journal ArticleDOI
Intracellular bacterial biofilm-like pods in urinary tract infections
Gregory G. Anderson,Joseph J. Palermo,Joel D. Schilling,Robyn Roth,John E. Heuser,Scott J. Hultgren +5 more
TL;DR: It is discovered that the intracellular bacteria matured into biofilms, creating pod-like bulges on the bladder surface, which explains how bladder infections can persist in the face of robust host defenses.
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Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy
TL;DR: Together, these images suggest how NSF could dissociate the SNARE complex and how association and dissociation of the complex could be related to membrane fusion.
Journal ArticleDOI
Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli.
Matthew A. Mulvey,Yolanda S. López-Boado,Carole L. Wilson,Robyn Roth,William C. Parks,John E. Heuser,Scott J. Hultgren +6 more
TL;DR: Bacterial attachment resulted in exfoliation of host bladder epithelial cells as part of an innate host defense system through a rapid apoptosis-like mechanism involving caspase activation and host DNA fragmentation.
Journal ArticleDOI
Induction and Evasion of Host Defenses by Type 1-Piliated Uropathogenic Escherichia Coli
Matthew A. Mulvey,Yolanda S. López-Boado,Carole L. Wilson,Robyn Roth,William C. Parks,John E. Heuser,Scott J. Hultgren +6 more
TL;DR: Bacterial attachment resulted in exfoliation of host bladder epithelial cells as part of an innate host defense system through a rapid apoptosis-like mechanism involving caspase activation and host DNA fragmentation.