M
Meng Ling Choong
Researcher at Agency for Science, Technology and Research
Publications - 27
Citations - 1174
Meng Ling Choong is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Janus kinase 2 & Kinase. The author has an hindex of 15, co-authored 27 publications receiving 1076 citations. Previous affiliations of Meng Ling Choong include National University of Singapore & Johns Hopkins University.
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Journal ArticleDOI
Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants
Ilyas Chachoua,Ilyas Chachoua,Christian Pecquet,Christian Pecquet,Mira El-Khoury,Harini Nivarthi,Roxana-Irina Albu,Roxana-Irina Albu,Caroline Marty,Vitalina Gryshkova,Vitalina Gryshkova,Jean-Philippe Defour,Jean-Philippe Defour,Gaëlle Vertenoeil,Gaëlle Vertenoeil,Anna Ngo,Ann Koay,Hana Raslova,Pierre J. Courtoy,Meng Ling Choong,Isabelle Plo,William Vainchenker,Robert Kralovics,Stefan N. Constantinescu,Stefan N. Constantinescu +24 more
TL;DR: This study provides a novel signaling paradigm, whereby a mutated chaperone constitutively activates cytokine receptor signaling, and knocking down either MPL/TpoR or JAK2 in megakaryocytic progenitors from patients carrying CALR mutations inhibited cytokine-independent megakARYocytic colony formation.
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MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis.
TL;DR: B Probable signature miRNAs for erythropoiesis are identified and are predicted to target genes involved in cell development and differentiation.
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Stapled Peptides with Improved Potency and Specificity That Activate p53
Christopher J. Brown,Soo Tng Quah,Janice Jong,Amanda M. Goh,Poh C. Chiam,Kian Hoe Khoo,Meng Ling Choong,May A. Lee,Larisa Yurlova,Kourosh Zolghadr,Thomas Leonard Joseph,Chandra S. Verma,Chandra S. Verma,Chandra S. Verma,David P. Lane +14 more
TL;DR: By using a phage display derived peptide as an initial template, compounds have been developed that are highly specific against Mdm2/Mdm4, suggesting they are highly suitable for cyclotherapy.
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Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy.
TL;DR: Low doses of actinomycin D mimic nutlin-3 in the highly specific activation of p53 dependant transcription, in the induction of a reversible protective growth arrest in normal cells and in the enhancement of the activity of chemotherapeutic drug induced killing of p 53 positive human tumor cells.
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Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors.
Meng Ling Choong,Christian Pecquet,Vishal Pendharkar,Carmen C. Diaconu,Jacklyn Wei Yan Yong,Shi Jing Tai,Si Fang Wang,Jean-Philippe Defour,Kanda Sangthongpitag,Jean-Luc Villeval,William Vainchenker,Stefan N. Constantinescu,May Ann Lee +12 more
TL;DR: The data support the use of a combination of JAK2 and pan‐class I PI3K inhibitors in the treatment of MPNs and show strong inhibitory effects on erythropoietin‐independent erythroid colonies from MPN patients and JAK 2 V617F knock‐in mice.