J
Jean-Philippe Defour
Researcher at Cliniques Universitaires Saint-Luc
Publications - 39
Citations - 1751
Jean-Philippe Defour is an academic researcher from Cliniques Universitaires Saint-Luc. The author has contributed to research in topics: Thrombopoietin receptor & Receptor. The author has an hindex of 18, co-authored 35 publications receiving 1285 citations. Previous affiliations of Jean-Philippe Defour include Catholic University of Leuven & Université catholique de Louvain.
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Journal ArticleDOI
What is the normal value of the neutrophil-to-lymphocyte ratio?
Patrice Forget,Patrice Forget,Céline Khalifa,Jean-Philippe Defour,Dominique Latinne,Marie Cécile Van Pel,Marc De Kock +6 more
TL;DR: It is identified that the normal NLR values in an adult, non-geriatric, population in good health are between 0.78 and 3.53.
Journal ArticleDOI
Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants
Ilyas Chachoua,Ilyas Chachoua,Christian Pecquet,Christian Pecquet,Mira El-Khoury,Harini Nivarthi,Roxana-Irina Albu,Roxana-Irina Albu,Caroline Marty,Vitalina Gryshkova,Vitalina Gryshkova,Jean-Philippe Defour,Jean-Philippe Defour,Gaëlle Vertenoeil,Gaëlle Vertenoeil,Anna Ngo,Ann Koay,Hana Raslova,Pierre J. Courtoy,Meng Ling Choong,Isabelle Plo,William Vainchenker,Robert Kralovics,Stefan N. Constantinescu,Stefan N. Constantinescu +24 more
TL;DR: This study provides a novel signaling paradigm, whereby a mutated chaperone constitutively activates cytokine receptor signaling, and knocking down either MPL/TpoR or JAK2 in megakaryocytic progenitors from patients carrying CALR mutations inhibited cytokine-independent megakARYocytic colony formation.
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Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients.
Xenia Cabagnols,Xenia Cabagnols,Fabrizia Favale,Fabrizia Favale,Florence Pasquier,Florence Pasquier,Kahia Messaoudi,Kahia Messaoudi,Jean-Philippe Defour,Jean-Philippe Defour,Jean Christophe Ianotto,Christophe Marzac,Jean Pierre Le Couédic,Jean Pierre Le Couédic,Nathalie Droin,Nathalie Droin,Ilyas Chachoua,Ilyas Chachoua,Rémi Favier,Rémi Favier,M'Boyba Diop,M'Boyba Diop,Valérie Ugo,Nicole Casadevall,Najet Debili,Najet Debili,Hana Raslova,Hana Raslova,Christine Bellanné-Chantelot,Stefan N. Constantinescu,Stefan N. Constantinescu,Olivier Bluteau,Olivier Bluteau,Isabelle Plo,Isabelle Plo,William Vainchenker +35 more
TL;DR: Functional studies on MPLS204P and MPLY591N revealed that they are weak gain-of-function mutants increasing MPL signaling and conferring either TPO hypersensitivity or independence to expressing cells, but with a low efficiency.
Journal ArticleDOI
Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution.
Xénia Cabagnols,Jean-Philippe Defour,Valérie Ugo,Jean-Christophe Ianotto,P Mossuz,J Mondet,François Girodon,J H Alexandre,Olivier Mansier,Jean-François Viallard,Eric Lippert,Anne Murati,M J Mozziconacci,Pascale Saussoy,Marie-Christiane Vekemans,Laurent Knoops,Florence Pasquier,Vincent Ribrag,Eric Solary,Isabelle Plo,Stefan N. Constantinescu,Nicole Casadevall,William Vainchenker,C Marzac,Olivier Bluteau +24 more
TL;DR: Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution is investigated.
Journal ArticleDOI
Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency
Maria Veiga-da-Cunha,Nathalie Chevalier,Xavier Stéphenne,Jean-Philippe Defour,Nicole Paczia,Alina Ferster,Younes Achouri,Joseph P. Dewulf,Carole L. Linster,Guido T. Bommer,Emile Van Schaftingen +10 more
TL;DR: The neutropenia in patients with G6PC3 or G6PT mutations is a metabolite-repair deficiency, caused by a failure to eliminate the nonclassical metabolite 1,5AG6P.