M
Mengli Wang
Researcher at Emory University
Publications - 3
Citations - 230
Mengli Wang is an academic researcher from Emory University. The author has contributed to research in topics: Messenger RNA & Neural stem cell. The author has an hindex of 2, co-authored 3 publications receiving 161 citations. Previous affiliations of Mengli Wang include Central South University.
Papers
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Journal ArticleDOI
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets.
Feiran Zhang,Yunhee Kang,Mengli Wang,Yujing Li,Tianlei Xu,Wei Yang,Hongjun Song,Hao Wu,Qiang Shu,Peng Jin +9 more
TL;DR: Biochemical analyses indicate that FMRP regulates the stability of its m6A‐marked mRNA targets through YTHDF2, which could potentially contribute to the molecular pathogenesis of FXS, and transcriptome‐wide gene expression profiling suggests that M6A is a widespread epitranscriptomic modification in brain.
Journal ArticleDOI
Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis.
Xuekun Li,Bing Yao,Li Chen,Yunhee Kang,Yujing Li,Ying Cheng,Liping Li,Li Lin,Zhiqin Wang,Mengli Wang,Feng Pan,Qing Dai,Wei Zhang,Hao Wu,Qiang Shu,Zhaohui S. Qin,Chuan He,Mingjiang Xu,Peng Jin,Peng Jin +19 more
TL;DR: 5hmC is elevated during the differentiation of adult neural stem cells (aNSCs), and Tet2 is primarily responsible for modulating 5hmC dynamics, and an important role is established for the Tet2-Foxo3a axis in epigenetically regulating critical genes in aN SCs during adult neurogenesis.
Journal ArticleDOI
Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats.
Bin Jiao,Mengli Wang,Mengli Wang,Hao Feng,Han Bao,Feiran Zhang,Hao Wu,Junling Wang,Beisha Tang,Peng Jin,Lu Shen +10 more
TL;DR: In this paper, the role of GGGGCC expanded repeats in Drosophila neurodegeneration and locomotion impairment has been investigated, and it was shown that knockdown of the DNA topoisomerase II (Top2) gene can specifically modulate GGG-GCC-associated neuro degeneration of the eye.