T
Tianlei Xu
Researcher at Emory University
Publications - 23
Citations - 1659
Tianlei Xu is an academic researcher from Emory University. The author has contributed to research in topics: Epitope & DNA methylation. The author has an hindex of 13, co-authored 23 publications receiving 1200 citations. Previous affiliations of Tianlei Xu include Chinese Academy of Sciences & Tongji University.
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Journal ArticleDOI
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Yi Lan Weng,Yi Lan Weng,Xu Wang,Ran An,Jessica Cassin,Caroline Vissers,Yuanyuan Liu,Yajing Liu,Tianlei Xu,Xinyuan Wang,Samuel Zheng Hao Wong,Jessica Joseph,Louis C. Dore,Qiang Dong,Wei Zheng,Peng Jin,Hao Wu,Bin Shen,Xiaoxi Zhuang,Chuan He,Kai Liu,Hongjun Song,Guo Li Ming +22 more
TL;DR: It is reported that sciatic nerve lesion elevates levels of m6A-tagged transcripts encoding many regeneration-associated genes and protein translation machinery components in the adult mouse dorsal root ganglion (DRG).
Journal ArticleDOI
Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates.
Hao Wu,Tianlei Xu,Hao Feng,Li Chen,Ben Li,Bing Yao,Zhaohui S. Qin,Peng Jin,Karen N. Conneely +8 more
TL;DR: A statistical method, DSS-single, is developed for detecting differentially methylated regions (DMRs) from WGBS data without replicates and it is demonstrated that using information from neighboring CG sites, biological variation can be estimated accurately even without replicate.
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Fat Mass and Obesity-associated (FTO) Protein Regulates Adult Neurogenesis.
Liping Li,Liping Li,Liqun Zang,Liqun Zang,Feiran Zhang,Junchen Chen,Junchen Chen,Hui Shen,Hui Shen,Liqi Shu,Liqi Shu,Feng Liang,Feng Liang,Chunyue Feng,Deng Chen,Huikang Tao,Tianlei Xu,Ziyi Li,Yunhee Kang,Hao Wu,Lichun Tang,Pumin Zhang,Peng Jin,Qiang Shu,Xuekun Li,Xuekun Li +25 more
TL;DR: It is shown that FTO is expressed in adult neural stem cells and neurons and displays dynamic expression during postnatal neurodevelopment and this results suggest FTO plays important roles in neurogenesis, as well as in learning and memory.
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Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice
Anuradha Rao,Astrid Kosters,Jamie E. Mells,Wujuan Zhang,Kenneth D.R. Setchell,Angélica M. Amanso,Grace M. Wynn,Tianlei Xu,Brad T. Keller,Hong Yin,Sophia Banton,Dean P. Jones,Hao Wu,Paul A. Dawson,Saul J. Karpen +14 more
TL;DR: It is suggested that blocking ASBT function with a luminally restricted apical sodium-dependent BA transporter (ASBT) inhibitor can improve both hepatic and whole body aspects of NAFLD.
Journal ArticleDOI
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets.
Feiran Zhang,Yunhee Kang,Mengli Wang,Yujing Li,Tianlei Xu,Wei Yang,Hongjun Song,Hao Wu,Qiang Shu,Peng Jin +9 more
TL;DR: Biochemical analyses indicate that FMRP regulates the stability of its m6A‐marked mRNA targets through YTHDF2, which could potentially contribute to the molecular pathogenesis of FXS, and transcriptome‐wide gene expression profiling suggests that M6A is a widespread epitranscriptomic modification in brain.