Mengmeng Zhang

TL;DR: This study identified 2-amino-5-chloro-N,3-dimethylbenzamide (CDDO), a compound known to inhibit heat shock protein 90 (HSP90), as an inhibitor of necroptosis that could also inhibit ferroptosis, and found that HSP90 defined a common regulatory nodal between necroPTosis and ferroPTosis.

TL;DR: It is concluded that pharmacological targeting of TRADD may represent a promising strategy for inhibiting cell death and restoring homeostasis to treat human diseases.

TL;DR: This study demonstrates the distinct roles of K612 ubiquitination in mRIPK1/K627 ubiquitinations in hRIPK 1 in regulating its pro-death kinase activity in response to TNFα and pro-survival activity in Response to TLRs signaling.

TL;DR: In this paper, the authors identify several compounds as inducers of PD-L1 degradation using a high-throughput drug screen and demonstrate the role of ARIH1 in anti-tumor immunity.

TL;DR: In this paper, the authors show that mutations in the NEK1 gene are associated with human developmental disorders and ALS, and they identify a molecular mechanism by which retromer trafficking and metabolism regulates cerebrovascular integrity, cerebral proteome homeostasis and RIPK1-mediated neuroinflammation.