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Daichao Xu
Researcher at Chinese Academy of Sciences
Publications - 26
Citations - 1411
Daichao Xu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: RIPK1 & Programmed cell death. The author has an hindex of 14, co-authored 18 publications receiving 964 citations. Previous affiliations of Daichao Xu include Harvard University & Zhejiang University.
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Journal ArticleDOI
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
Daichao Xu,Taijie Jin,Hong Zhu,Hongbo Chen,Dimitry Ofengeim,Chengyu Zou,Lauren Mifflin,Lifeng Pan,Palak Amin,Wanjin Li,Bing Shan,Masanori Gomi Naito,Huyan Meng,Ying Li,Heling Pan,Liviu Aron,Xian Adiconis,Joshua Z. Levin,Bruce A. Yankner,Junying Yuan,Junying Yuan +20 more
TL;DR: It is shown that in Tbk1+/- mice, the reduced myeloid TAK1 expression promotes all the key hallmarks of ALS/FTD, including neuroinflammation, TDP-43 aggregation, axonal degeneration, neuronal loss, and behavior deficits, which are blocked upon inhibition of RIPK1.
Journal ArticleDOI
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.
Jiefei Geng,Yasushi Ito,Linyu Shi,Palak Amin,Jiachen Chu,Amanda Tomie Ouchida,Adnan K. Mookhtiar,Heng Zhao,Daichao Xu,Bing Shan,Ayaz Najafov,Guangping Gao,Shizuo Akira,Junying Yuan,Junying Yuan +14 more
TL;DR: In this article, the authors show that TAK-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this critical decision.
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Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression.
Kezhou Zhu,Wei Liang,Zaijun Ma,Daichao Xu,Shuangyi Cao,Xiaojuan Lu,Nan Liu,Bing Shan,Lihui Qian,Junying Yuan,Junying Yuan +10 more
TL;DR: It is concluded that TNFα-induced necroptosis signaling events mediated by RIPK1 and RIPK3 activation, in addition to the MLKL oligomerization, promotes the expression of cytokines involving multiple intracellular signaling mechanisms including NF-κB pathway and p38.
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Facile synthesis of metal N-heterocyclic carbene complexes
TL;DR: A novel electrochemical procedure for the preparation of metal complexes of N-heterocyclic carbenes using imidazolium salts or corresponding silver-NHC complexes as carbene sources and electrolytes, and metal plates as the sacrificial anodes is described.
Journal ArticleDOI
USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1.
Daichao Xu,Bing Shan,Huawang Sun,Juan Xiao,Kezhou Zhu,Xingxing Xie,Xingyan Li,Wei Liang,Xiaojuan Lu,Lihui Qian,Junying Yuan +10 more
TL;DR: This study suggests that Akt-regulated USP14 activity modulates both proteasomal degradation and autophagy through controlling K48 and K63 ubiquitination, respectively.