M
Micah T. McClain
Researcher at Duke University
Publications - 91
Citations - 5724
Micah T. McClain is an academic researcher from Duke University. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 27, co-authored 71 publications receiving 4834 citations. Previous affiliations of Micah T. McClain include Oklahoma Medical Research Foundation & Center for Applied Genomics.
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Journal ArticleDOI
Development of autoantibodies before the clinical onset of systemic lupus erythematosus.
Melissa R. Arbuckle,Micah T. McClain,Mark V. Rubertone,R. Hal Scofield,Gregory J. Dennis,Judith A. James,John B. Harley +6 more
TL;DR: The onset and progression of autoantibody development before the clinical diagnosis of systemic lupus erythematosus is investigated, with a progressive accumulation of specificAutoantibodies before the onset of SLE, while patients are still asymptomatic.
Journal ArticleDOI
Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry.
Micah T. McClain,Latisha Heinlen,Latisha Heinlen,Gregory J. Dennis,Jon Roebuck,John B. Harley,John B. Harley,John B. Harley,Judith A. James,Judith A. James +9 more
TL;DR: The hypothesis that some humoral autoimmunity in human lupus arises through molecular mimicry between EBNA-1 and l upus autoantigens is supported and further evidence to suspect an etiologic role for Epstein-Barr virus in SLE is provided.
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Temporal Dynamics of Host Molecular Responses Differentiate Symptomatic and Asymptomatic Influenza A Infection
Yongsheng Huang,Aimee K. Zaas,Arvind Rao,Nicolas Dobigeon,Peter J. Woolf,Timothy Veldman,N. Christine Øien,Micah T. McClain,Jay B. Varkey,Bradley Nicholson,Lawrence Carin,Stephen F. Kingsmore,Christopher W. Woods,Geoffrey S. Ginsburg,Alfred O. Hero +14 more
TL;DR: An asymptomatic host-unique non-passive response signature is revealed, suggesting novel putative molecular targets for both prognostic assessment and ameliorative therapeutic intervention in seasonal and pandemic influenza.
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Host gene expression classifiers diagnose acute respiratory illness etiology.
Ephraim L. Tsalik,Ephraim L. Tsalik,Ephraim L. Tsalik,Ricardo Henao,Marshall Nichols,Thomas W. Burke,Emily R Ko,Micah T. McClain,Micah T. McClain,Micah T. McClain,Lori L. Hudson,Anna Mazur,D. Freeman,Tim Veldman,Raymond J. Langley,Eugenia Quackenbush,Seth W. Glickman,Charles B. Cairns,Charles B. Cairns,Anja Kathrin Jaehne,Emanuel P. Rivers,Ronny M. Otero,Aimee K. Zaas,Stephen F. Kingsmore,Joseph Lucas,Vance G. Fowler,Lawrence Carin,Geoffrey S. Ginsburg,Christopher W. Woods,Christopher W. Woods,Christopher W. Woods +30 more
TL;DR: Clear differences in host gene expression induced by bacterial and viral infection as well as by noninfectious illness are reported, creating an opportunity to develop and use host gene Expression classifiers as diagnostic platforms to combat inappropriate antibiotic use and emerging antibiotic resistance.
Journal ArticleDOI
Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms.
Latisha Heinlen,Micah T. McClain,Micah T. McClain,Joan T. Merrill,Joan T. Merrill,Yasmin W. Akbarali,Yasmin W. Akbarali,Colin C. Edgerton,John B. Harley,Judith A. James +9 more
TL;DR: Symptoms associated with the ACR criteria for classification of SLE are commonly present before the diagnosis of Sle, and development of organ-associated autoantibodies generally precedes the appearance of their associated clinical features.