Jay B. Varkey

TL;DR: There was a concomitant decline in the amount of virus detected in plasma as the patients' condition improved clinically, and aggressive supportive measures of hydration and electrolyte correction were undertaken.

TL;DR: Sustained immune activation after the virus was cleared from the plasma is found, observed most strikingly in the persistence of activated CD8 T cells, even 1 mo after the patients’ discharge from the hospital, suggesting continued antigen stimulation after resolution of the disease.

TL;DR: An asymptomatic host-unique non-passive response signature is revealed, suggesting novel putative molecular targets for both prognostic assessment and ameliorative therapeutic intervention in seasonal and pandemic influenza.

TL;DR: While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date.

TL;DR: The clinical course and management of the index case patient and 2 nurses who developed EVD after caring for him and the first 2 patients with EBOV infection acquired in the United States are described.