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Michael Aviram

Researcher at Technion – Israel Institute of Technology

Publications -  489
Citations -  32705

Michael Aviram is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 94, co-authored 479 publications receiving 31141 citations. Previous affiliations of Michael Aviram include University of Tromsø & Steward Health Care System.

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Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.

TL;DR: It is concluded that HDL-associated PON possesses peroxidase-like activity that can contribute to the protective effect of PON against lipoprotein oxidation, and may be a major contributor to the antiatherogenicity of this lipop Protein.
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Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation

TL;DR: The antioxidant effect of dietary red wine on plasma lipid peroxidation was not secondary to changes in the plasma vitamin E or beta-carotene content but could be related to the elevation of polyphenol concentration in plasma and LDL.
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Comparison of Antioxidant Potency of Commonly Consumed Polyphenol-Rich Beverages in the United States

TL;DR: Although in vitro antioxidant potency does not prove in vivo biological activity, there is also consistent clinical evidence of antioxidant potency for the most potent beverages including both PJ and red wine.
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Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants.

TL;DR: PON's ability to protect LDL against oxidation is accompanied by inactivation of the enzyme, suggesting the interaction of oxidized lipids in Ox-LDL with the PON's free sulfhydryl group.