M
Michael Aviram
Researcher at Technion – Israel Institute of Technology
Publications - 489
Citations - 32705
Michael Aviram is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 94, co-authored 479 publications receiving 31141 citations. Previous affiliations of Michael Aviram include University of Tromsø & Steward Health Care System.
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Journal ArticleDOI
Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages.
TL;DR: It is concluded that PJ-mediated suppression of Ox-LDL degradation and of cholesterol biosynthesis in macrophages can lead to reduced cellular cholesterol accumulation and foam cell formation.
Journal ArticleDOI
Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies.
Mira Rosenblat,Michael Aviram +1 more
TL;DR: In this article, the role of macrophage reduced glutathione (GSH) and peroxidase (GPx) in low-density lipoprotein (LDL) oxidation was investigated.
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Defective high-density lipoprotein composition in patients on chronic hemodialysis. A possible mechanism for accelerated atherosclerosis.
TL;DR: In patients on chronic hemodialysis with Type IV hyperlipoproteinemia, a major factor in the atherosclerosis of these patients may be their abnormal high-density lipoprotein composition, which could be due to defective lipop protein lipase activation by the reduced very-low-densitylipoprotein apoprotein.
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Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPARγ and AP-1 pathway activation
TL;DR: It is concluded that the anti-oxidative characteristics of PJ unique phenolics punicalagin and gallic acid could be related, at least in part, to their stimulatory effect on macrophage PON2 expression, a phenomenon which was shown to be associated with activation of the transcription factors PAPR gamma and AP-1.
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Structural aspects of the inhibitory effect of glabridin on ldl oxidation
TL;DR: The results suggest that the antioxidant effect of glabridin on LDL oxidation appears to reside mainly in the 2' hydroxyl, and that the hydrophobic moiety of the isoflavan is essential to obtain this effect.