Michael Bouvet

TL;DR: The simple, noninvasive, and highly selective imaging of growing tumors, made possible by strong GFP fluorescence, enables the detailed imaging of tumor growth and metastasis formation and should facilitate studies of modulators of cancer growth including inhibition by potential chemotherapeutic agents.

TL;DR: Restoration of wild-type p53 expression may decrease tumor growth by inhibiting the angiogenic response and explain, in part, the bystander effect seen with p53 tumor suppressor gene therapy.

TL;DR: The development of subcellular real-time imaging of cancer cell trafficking in live mice will enable further understanding of the critical steps of metastasis and provide visible targets for antimetastasis drug development.

TL;DR: It is important to keep in mind that the thyroid gland can be a site of metastases for a variety of tumors when evaluating a thyroid nodule, especially in a patient with a prior history of malignancy.

TL;DR: The GFP imaging technology presented in this report will facilitate studies of modulators of pancreatic cancer growth, including inhibition by potential chemotherapeutic agents, and provide unprecedented continuous visual monitoring of malignant growth and spread within intact animals without the need for anesthesia, substrate injection, contrast agents, or restraint of animals required by other imaging methods.