M
Meng Yang
Researcher at University of California, San Diego
Publications - 119
Citations - 10874
Meng Yang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Metastasis & Green fluorescent protein. The author has an hindex of 50, co-authored 101 publications receiving 10399 citations. Previous affiliations of Meng Yang include Yokohama City University.
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Journal ArticleDOI
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.
Clemens A. Schmitt,Jordan S. Fridman,Meng Yang,Soyoung Lee,Eugene Baranov,Robert M. Hoffman,Scott W. Lowe +6 more
TL;DR: It is shown that primary murine lymphomas also respond to chemotherapy by engaging a senescence program controlled by p53 and p16(INK4a), and mice bearing tumors capable of drug-induced senescENCE have a much better prognosis following chemotherapy than those harboring tumors with senescences defects.
Journal ArticleDOI
Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases
Meng Yang,Eugene Baranov,Ping Jiang,Fang-Xian Sun,Xiao-Ming Li,Lingna Li,Satoshi Hasegawa,Michael Bouvet,Maraya Al-Tuwaijri,Takashi Chishima,Hiroshi Shimada,A. R. Moossa,Sheldon Penman,Robert M. Hoffman +13 more
TL;DR: The simple, noninvasive, and highly selective imaging of growing tumors, made possible by strong GFP fluorescence, enables the detailed imaging of tumor growth and metastasis formation and should facilitate studies of modulators of cancer growth including inhibition by potential chemotherapeutic agents.
Journal ArticleDOI
Dissecting p53 tumor suppressor functions in vivo
Clemens A. Schmitt,Jordan S. Fridman,Meng Yang,Eugene Baranov,Robert M. Hoffman,Scott W. Lowe +5 more
TL;DR: It is shown that disruption of apoptosis downstream of p53 by Bcl2 or a dominant-negative caspase 9 confers-like p53 loss-a selective advantage, and completely alleviates pressure to inactivate p53 during lymphomagenesis, which is the only p53 function selected against during lymphoma development.
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Biomimetic amplification of nanoparticle homing to tumors
Dmitri Simberg,Tasmia Duza,Ji-Ho Park,Markus Essler,Jan Pilch,Lianglin Zhang,Austin M. Derfus,Austin M. Derfus,Meng Yang,Robert M. Hoffman,Sangeeta N. Bhatia,Sangeeta N. Bhatia,Michael J. Sailor,Erkki Ruoslahti,Erkki Ruoslahti +14 more
TL;DR: Bi biomimetic particles that not only home to tumors, but also amplify their own homing are described, which greatly enhances tumor imaging, and the addition of a drug carrier function to the particles is envisioned.
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Transdifferentiation of glioblastoma cells into vascular endothelial cells
Yasushi Soda,Tomotoshi Marumoto,Tomotoshi Marumoto,Dinorah Friedmann-Morvinski,Mie Soda,Fei Liu,Hiroyuki Michiue,Sandra Pastorino,Meng Yang,Robert M. Hoffman,Santosh Kesari,Inder M. Verma +11 more
TL;DR: It is suggested that the TDEC is an important player in the resistance to anti-VEGF therapy, and hence a potential target for GBM therapy.