M
Michael F. Jantsch
Researcher at Medical University of Vienna
Publications - 88
Citations - 6785
Michael F. Jantsch is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: RNA editing & RNA. The author has an hindex of 36, co-authored 82 publications receiving 5982 citations. Previous affiliations of Michael F. Jantsch include Netherlands Cancer Institute & Max F. Perutz Laboratories.
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Journal ArticleDOI
Systematic identification of abundant A-to-I editing sites in the human transcriptome
Erez Y. Levanon,Erez Y. Levanon,Eli Eisenberg,Rodrigo Yelin,Sergey Nemzer,Martina Hallegger,Ronen Shemesh,Zipora Y. Fligelman,Avi Shoshan,Sarah Pollock,Dan Sztybel,Moshe Olshansky,Gideon Rechavi,Michael F. Jantsch +13 more
TL;DR: A computational search for ADAR editing sites in the human transcriptome is described, using millions of available expressed sequences and indicates the role of editing in controlling dsRNA stability.
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PARP is important for genomic stability but dispensable in apoptosis
Zhao-Qi Wang,Laura Stingl,Ciaran G. Morrison,Michael F. Jantsch,Marek Los,Klaus Schulze-Osthoff,Erwin F. Wagner +6 more
TL;DR: Although PARP is specifically cleaved during apoptosis, cells lacking this molecule apoptosed normally in response to treatment with anti-Fas, tumor neurosis factor alpha, gamma-irradiation, and dexamethasone, indicating thatPARP is dispensable in apoptosis and that PARP-/- thymocytes are not hypersensitive to ionizing radiation.
Journal ArticleDOI
A conserved double-stranded RNA-binding domain.
TL;DR: On the basis of the binding studies and computer analysis, a consensus sequence is derived that defines a 65- to 68-amino acid dsRNA-binding domain, the minimal region that binds ds RNA.
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The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA
Niamh M. Mannion,Sam M. Greenwood,Robert Young,Sarah L. Cox,James Brindle,David Read,Christoffer Nellåker,Cornelia Vesely,Chris P. Ponting,Paul J. McLaughlin,Michael F. Jantsch,Julia R. Dorin,Ian R. Adams,A. D. J. Scadden,Marie Öhman,Liam Keegan,Mary A O'Connell,Mary A O'Connell +17 more
TL;DR: In this article, inosine in cellular RNA inhibits antiviral inflammatory and interferon responses by altering RLR interactions and restoring the expression of editing-active cytoplasmic ADARs.
Journal ArticleDOI
A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction
Pawel Pasierbek,Michael F. Jantsch,Martin Melcher,Alexander Schleiffer,Dieter Schweizer,Josef Loidl +5 more
TL;DR: The depletion of C. elegans W02A2.6p (called REC-8) by RNAi, induced univalent formation and splitting of chromosomes into sister chromatids at diakinesis, and the occurrence of DSBs in REC- 8-depleted meiocytes suggests that DSB formation does not depend on homologous synapsis.