A
Alexander Schleiffer
Researcher at Research Institute of Molecular Pathology
Publications - 92
Citations - 8150
Alexander Schleiffer is an academic researcher from Research Institute of Molecular Pathology. The author has contributed to research in topics: Chromosome segregation & Cohesin. The author has an hindex of 41, co-authored 78 publications receiving 7326 citations. Previous affiliations of Alexander Schleiffer include Institute of Molecular Biotechnology & University of Vienna.
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Journal ArticleDOI
Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.
TL;DR: This and a previous study have identified six proteins essential for establishing or maintaining sister chromatid cohesion, four of which are subunits of a 'Cohesin' complex that binds chromosomes from late G1 until the onset of anaphase.
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Wapl Controls the Dynamic Association of Cohesin with Chromatin
Stephanie Kueng,Björn Hegemann,Beate H. Peters,Jesse J. Lipp,Alexander Schleiffer,Karl Mechtler,Jan-Michael Peters +6 more
TL;DR: It is shown that the interaction between cohesin and chromatin is controlled by Wapl, a protein implicated in heterochromatin formation and tumorigenesis, and that Wapl is required to unlock cohes in from a particular state in which it is stably bound to chromatin.
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Systematic analysis of human protein complexes identifies chromosome segregation proteins.
James R. A. Hutchins,Yusuke Toyoda,Björn Hegemann,Ina Poser,Jean-Karim Hériché,Martina M. Sykora,Martina Augsburg,Otto Hudecz,Bettina A. Buschhorn,Jutta Bulkescher,Christian Conrad,David Comartin,David Comartin,Alexander Schleiffer,Mihail Sarov,Andrei Pozniakovsky,Mikolaj Slabicki,Siegfried Schloissnig,Siegfried Schloissnig,Ines Steinmacher,Marit Leuschner,Andrea Ssykor,Steffen Lawo,Steffen Lawo,Laurence Pelletier,Holger Stark,Kim Nasmyth,Jan Ellenberg,Richard Durbin,Frank Buchholz,Karl Mechtler,Anthony A. Hyman,Jan-Michael Peters +32 more
TL;DR: The approaches described here are generally applicable to high-throughput follow-up analyses of phenotypic screens in mammalian cells and led to the discovery of previously unknown, evolutionarily conserved subunits of the anaphase-promoting complex and the γ-tubulin ring complex—large complexes that are essential for spindle assembly and chromosome segregation.
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Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl
Tomoko Nishiyama,Rene Ladurner,Julia Schmitz,Emanuel Kreidl,Alexander Schleiffer,Venugopal Bhaskara,Masashige Bando,Katsuhiko Shirahige,Anthony A. Hyman,Karl Mechtler,Jan-Michael Peters +10 more
TL;DR: It is proposed that Sororin maintains cohesion by inhibiting Wapl's ability to dissociate cohesin from DNA, and that one of these, Dalmatian, is essential for cohesion in Drosophila.
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A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction
Pawel Pasierbek,Michael F. Jantsch,Martin Melcher,Alexander Schleiffer,Dieter Schweizer,Josef Loidl +5 more
TL;DR: The depletion of C. elegans W02A2.6p (called REC-8) by RNAi, induced univalent formation and splitting of chromosomes into sister chromatids at diakinesis, and the occurrence of DSBs in REC- 8-depleted meiocytes suggests that DSB formation does not depend on homologous synapsis.