M
Michael G. Levin
Researcher at University of Pennsylvania
Publications - 55
Citations - 2489
Michael G. Levin is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Mendelian randomization & Coronary artery disease. The author has an hindex of 16, co-authored 51 publications receiving 1748 citations. Previous affiliations of Michael G. Levin include University of Texas Southwestern Medical Center & Hospital of the University of Pennsylvania.
Papers
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Journal ArticleDOI
HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells
Fatiha Tabet,Kasey C. Vickers,Luisa F. Cuesta Torres,Carrie B. Wiese,Bassem M. Shoucri,Gilles Lambert,Claire Catherinet,Leonel Prado-Lourenco,Michael G. Levin,Seth G. Thacker,Praveen Sethupathy,Philip J. Barter,Alan T. Remaley,Kerry-Anne Rye +13 more
TL;DR: It is demonstrated that HDL's anti-inflammatory properties are conferred, in part, through HDL-miR-223 delivery and translational repression of ICAM-1 in endothelial cells.
Journal ArticleDOI
The Diagnostic Accuracy of Ex Vivo MRI for Human Atherosclerotic Plaque Characterization
Meir Shinnar,John T. Fallon,Suzanne Wehrli,Michael G. Levin,Dolcine Dalmacy,Zahi A. Fayad,Juan J. Badimon,Martin Harrington,Elizabeth O. Harrington,Valentin Fuster +9 more
TL;DR: MRI can characterize carotid artery plaques with a high level of sensitivity and specificity and Application of these results in the clinical setting may be feasible in the near future.
Journal ArticleDOI
MicroRNA-223 coordinates cholesterol homeostasis.
Kasey C. Vickers,Kasey C. Vickers,Landstreet,Michael G. Levin,Bassem M. Shoucri,Cynthia L. Toth,Ronald C. Taylor,Brian T. Palmisano,Fatiha Tabet,HL Cui,Kerry-Anne Rye,Praveen Sethupathy,Alan T. Remaley +12 more
TL;DR: A critical role is identified in systemic cholesterol regulation by coordinated posttranscriptional control of multiple genes in lipoprotein and cholesterol metabolism by microRNA-223 (miR-223), an miRNA previously associated with inflammation.
Journal ArticleDOI
MicroRNA-27b is a regulatory hub in lipid metabolism and is altered in dyslipidemia.
Kasey C. Vickers,Bassem M. Shoucri,Michael G. Levin,Han Wu,Daniel S. Pearson,David Osei-Hwedieh,Francis S. Collins,Alan T. Remaley,Praveen Sethupathy +8 more
TL;DR: In this paper, the authors performed high-throughput small RNA sequencing and detected ≈150 miRNAs in mouse liver, and employed an unbiased, in silico strategy to identify miRNA regulatory hubs in lipid metabolism, and miR-27b was identified as the strongest such hub in human and mouse liver.
Journal Article
Abstract 24: MicroRNA-27b Is a Regulatory Hub in Lipid Metabolism and Is Altered in Dyslipidemia
Kasey C. Vickers,Bassem M. Shoucri,Michael G. Levin,Han Wu,David Osei-Hwedieh,Daniel S. Pearson,Francis S. Collins,Praveen Sethupathy,Alan T. Remaley +8 more
TL;DR: It is shown in a human hepatocyte cell line that miR‐27b regulates the expression (messenger RNA and protein) of several key lipid‐metabolism genes, including Angptl3 and Gpam, and it is demonstrated that hepatic miR-27b and its target genes are inversely altered in a mouse model of dyslipidemia and atherosclerosis.