M
Michael G. Rosenfeld
Researcher at University of California, San Diego
Publications - 522
Citations - 112098
Michael G. Rosenfeld is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Transcription factor & Regulation of gene expression. The author has an hindex of 178, co-authored 504 publications receiving 107707 citations. Previous affiliations of Michael G. Rosenfeld include Tokai University & Salk Institute for Biological Studies.
Papers
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Journal ArticleDOI
Hormonal stimulation of alpha-amylase synthesis in porcine pancreatic minces.
TL;DR: Minces of porcine pancreas maintained a linear rate or protein synthesis for more than 4 h with similar kinetics in the presence of absence of hormones, suggesting that these agents produced at least 3- to 5-fold stimulation of de novo alpha-amylase synthesis.
Journal ArticleDOI
Function of the conserved Pit-1 gene distal enhancer in progenitor and differentiated pituitary cells.
TL;DR: The functional conservation of the distal enhancer element suggests that it is crucial to the maintenance and cell-specific regulation of the Pit-1 gene.
Journal ArticleDOI
The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation.
Claudio Scafoglio,Claudio Scafoglio,Marcus B. Smolka,Marcus B. Smolka,Huilin Zhou,Valentina Perissi,Valentina Perissi,Michael G. Rosenfeld,Michael G. Rosenfeld +8 more
TL;DR: It is found that Chk2 interacts with members of the NCoR/SMRT transcriptional co-regulator complexes and serves as a functional component of the repressor complex, being required for recruitment of SMRT on the promoter of pro-apoptotic genes upon DNA damage.
Book ChapterDOI
Complexity of the RAR‐mediated transcriptional regulatory programs
TL;DR: Key questions in the NR field have included: what are the cofactors and exchange complexes used to mediate the ligand and signaling network-dependent switches in gene regulation programs, and do enhancers actually regulate transcription units encoding enhancer Enhancer non-coding RNAs (eRNAs) Enhancer RNA that might have functional significance.