M
Michael G. Rosenfeld
Researcher at University of California, San Diego
Publications - 522
Citations - 112098
Michael G. Rosenfeld is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Transcription factor & Regulation of gene expression. The author has an hindex of 178, co-authored 504 publications receiving 107707 citations. Previous affiliations of Michael G. Rosenfeld include Tokai University & Salk Institute for Biological Studies.
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Journal ArticleDOI
ASF/SF2-Regulated CaMKIIδ Alternative Splicing Temporally Reprograms Excitation-Contraction Coupling in Cardiac Muscle
Xiangdong Xu,Dongmei Yang,Jian-Hua Ding,Wang Wang,Pao-Hsien Chu,Nancy D. Dalton,Huan You Wang,John R. Bermingham,Zhen Ye,Forrest Liu,Michael G. Rosenfeld,James L. Manley,John Ross,Ju Chen,Rui-Ping Xiao,Heping Cheng,Xiang-Dong Fu +16 more
TL;DR: This work identifies the essential splicing factor ASF/SF2 as a key component of the program, regulating a restricted set of tissue-specific alternative splicing events during heart remodeling, and identifies CaMKIIdelta as a fundamental splicing regulator in the reprogramming pathway.
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Biological roles and mechanistic actions of co-repressor complexes.
TL;DR: Both N-CoR and SMRT are important targets for cell signaling pathways, which influence their expression levels, subcellular localization and association with other proteins, and the biological importance of these proteins has been revealed by studies of genetically engineered mice and human diseases.
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Calcitonin gene-related peptide in cardiovascular tissues of the rat
TL;DR: The results of this study suggest that calcitonin gene-related peptide-containing fibres are likely to be of importance in the innervation of vascular tissues and raise the possibility that these fibres may be different in character from calcitonIn gene- related peptides found in other tissues.
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A c- erb-A binding site in rat growth hormone gene mediates trans -activation by thyroid hormone
Christopher K. Glass,Rodrigo Franco,Cary Weinberger,Vivian R. Albert,Ronald M. Evans,Ronald M. Evans,Michael G. Rosenfeld,Michael G. Rosenfeld +7 more
TL;DR: An avidin–biotin complex DNA-binding assay is described which can detect specific, high-affinity binding of rat pituitary cell T3 receptors to the sequence 5'CAGGGACGTGACCGCA3', located 164 base pairs 5' to the transcriptional start site of the rat growth hormone gene.
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Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release
Wen Liu,Wen Liu,Qi Ma,Kaki Wong,Wenbo Li,Kenny Ohgi,Jie Zhang,Aneel K. Aggarwal,Michael G. Rosenfeld +8 more
TL;DR: A unique cohort of jumonji C-domain-containing protein 6 (JMJD6) and bromodomain-containingprotein 4 (Brd4) cobound distal enhancers, termed anti-pause enhancers (A-PEs), regulate promoter-proximal pause release of a large subset of transcription units via long-range interactions.