M
Michael Isaacson
Researcher at University of California, Santa Cruz
Publications - 94
Citations - 5081
Michael Isaacson is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Near-field scanning optical microscope & Scanning confocal electron microscopy. The author has an hindex of 26, co-authored 94 publications receiving 4932 citations. Previous affiliations of Michael Isaacson include Cornell University.
Papers
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Journal ArticleDOI
Brain responses to micro-machined silicon devices.
Donald H. Szarowski,M. D. Andersen,Scott T. Retterer,Andrew J. Spence,Michael Isaacson,Harold G. Craighead,James N. Turner,James N. Turner,William Shain,William Shain +9 more
TL;DR: Data indicate that device insertion promotes an early response proportional to device size and a sustained response that is independent of device size, geometry, and surface roughness, which may be associated with the amount of damage generated during insertion.
Journal ArticleDOI
Development of a 500 Å spatial resolution light microscope: I. light is efficiently transmitted through λ/16 diameter apertures
TL;DR: In this paper, the authors describe the possibility of constructing a scanning optical microscope based on near field imaging which could potentially have spatial resolutions as small as one-tenth the wavelength of the incident light.
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Cerebral Astrocyte Response to Micromachined Silicon Implants
James N. Turner,James N. Turner,James N. Turner,William Shain,William Shain,Donald H. Szarowski,M. Andersen,M. Andersen,S. Martins,Michael Isaacson,Harold G. Craighead +10 more
TL;DR: It was concluded that reactive gliosis is an important part of the process forming the cellular sheath, at least partially composed of reactive glia, which isolates the probe from the brain.
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Patterned Protein Layers on Solid Substrates by Thin Stamp Microcontact Printing
Conrad D. James,Robert C. Davis,Lance C. Kam,Lance C. Kam,Harold G. Craighead,Michael Isaacson,James N. Turner,James N. Turner,William Shain,William Shain +9 more
TL;DR: The extension of microcontact printing to producing patterned layers of proteins on solid substrates is presented, and the methods of thin stamp micro Contact printing that allow printing of isolated features previously unattainable by micro contact printing are described.
Journal ArticleDOI
Controlling cellular reactive responses around neural prosthetic devices using peripheral and local intervention strategies
William Shain,L. Spataro,J. Dilgen,K. Haverstick,Scott T. Retterer,Michael Isaacson,M. Saltzman,James N. Turner +7 more
TL;DR: It is demonstrated that peripheral delivery of dexamethasone can be used to control reactive responses and that local drug delivery by slow-release from biocompatible polymers may be a more effective method of drug intervention.