Michael J. Mack

TL;DR: Among patients with heart failure and moderate‐to‐severe or severe secondary mitral regurgitation who remained symptomatic despite the use of maximal doses of guideline‐directed medical therapy, transcatheter mitral‐valve repair resulted in a lower rate of hospitalization forHeart failure and lower all‐cause mortality within 24 months of follow‐up than medical therapy alone.

TL;DR: CABG should remain the standard of care for patients with complex lesions (high or intermediate SYNTAX scores) or left main coronary disease (low or intermediateSYNTAx scores), PCI is an acceptable alternative.

TL;DR: TAVR with SAPIEN 3 in intermediate-risk patients with severe aortic stenosis is associated with low mortality, strokes, and regurgitation at 1 year after implantation, and a significant superiority for the composite outcome with TAVR compared with surgery is indicated.

TL;DR: This work sought to synthesize the existing body of evidence and offer a perspective on how to integrate frailty into clinical practice and contribute valuable prognostic insights incremental to existing risk models and assists clinicians in defining optimal care pathways for their patients.

TL;DR: TAVR should be strongly considered for patients who are not surgical candidates for aortic valve replacement to improve their survival and functional status, and Appropriate selection of patients will help to maximise the benefit of TAVR and reduce mortality from severe comorbidities.